50350-34-0Relevant academic research and scientific papers
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
Cheng, Jie-Fei,Mak, Chi Ching,Huang, Yujin,Penuliar, Richard,Nishimoto, Masahiro,Zhang, Lin,Chen, Mi,Wallace, David,Arrhenius, Thomas,Chu, Donald,Yang, Guang,Barbosa, Miguel,Barr, Rick,Dyck, Jason R.B.,Lopaschuk, Gary D.,Nadzan, Alex M.
, p. 3484 - 3488 (2007/10/03)
A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucos
