50355-44-7Relevant academic research and scientific papers
pH dependent structural interconversion of 2-(2-hydroxy-benzylidene)-cyclohexan-1-one: Crystal structures and spectroscopic investigation
Pan?, Ana-Maria,P?u?escu, Iulia,Shova, Sergiu,Badea, Valentin,Tudose, Ramona,Silion, Mihaela,Costi?or, Otilia,Cseh, Liliana
, p. 9 - 16 (2017)
The behavior of 2-(2-hydroxy-benzylidene)-cyclohexan-1-one (BC) in the acidic and basic media was investigated. In acidic conditions a new dimeric structure 4′a-methoxy-2,2′,3,3′,4′,4′a,9′,9′a-octahydro-1H, 1′H-4,9′-bixanthene (XTC) was isolated. The stru
Synthesis and biological activities of some new C-Aminomethylation of 5H-5-Aryl-6,7,8,9-tetrahydrothiazolo[2,3-b]quinazolin-3(2H)-one and 6H-6-Aryl-2,3,7,8,9,10-hexahydrothiazino[2,3-b]quinazolin-4(3H)-one
Kumaraswamy, Damerakonda,Mallareddy
, p. 2231 - 2235 (2016/07/21)
The synthesis of 5H-5-aryl-6,7,8,9-tetrahydrothiazolo[2,3-b]quinazolin-3(2H)-one and 6H-6-aryl-2,3,7,8,9,10-hexahydrothiazino[2,3-b]quinazolin-4(3H)-one, reaction between 4-aryl-3,4,5,6,7,8-hexahydroquinazolin-2-thione and methyl chloroacetate and ethyl β-bromo propionate. The Mannich reaction on 5H-5-aryl-6,7,8,9-tetrahydrothiazolo[2,3-b]quinazolin-3(2H)-one and 6H-6-aryl-2,3,7,8,9,10-hexahydrothiazino[2,3-b]quinazolin-4(3H)-one in ethanol, aqueous formaldehyde and different secondary amines yielded a single product C-Mannich base in each case. The obtained C-Mannich bases (compounds VIII and X) have been characterized on the basis of analytical spectral data. These C-Mannich bases have been screened for their antibacterial, antifungal, anti-inflammatory and analgesic activities.
Modified calcium oxide as stable solid base catalyst for Aldol condensation reaction
Tang, Ying,Xu, Jingfang,Gu, Xuefan
, p. 313 - 320 (2013/07/26)
A highly efficient and stable solid-base catalyst for Aldol condensation was prepared by modifying commercial CaO with benzyl bromide in a simple way. It was found that modified CaO can effectively catalyse the Aldol condensation of cyclohexanone and benzaldehyde, as well as various benzaldehydes, to produce 2-benzylidenecyclohexanone with a good selectivity and high yield. Higher yield of 95.8% was obtained over modified CaO after 3 h, which is short compared with the yield of 92.1% after 12 h over commercial CaO. The influence of several reaction parameters, such as temperature, catalyst loading, was investigated. The humidity test over modified CaO reveals that the basic centres of modified CaO are stable for CO2 and moisture. From the results of Fourier transform-infrared (FT-IR) and Thermogravity analysis (TG) characterization, the modifier was bonded on surface of CaO chemically and almost no Ca(OH) 2 formed during the modification process. The type of aldehyde has great influence on the yield of aldol condensation.
Synthesis of novel 6,7,8,9-tetrahydro-5h-5-hydroxyphenyl-2-benzylidine- 3-substituted hydrazino thiazolo (2,3-b) quinazoline as potent antinociceptive and anti-inflammatory agents
Selvam, T. Panneer,Kumar, P. Vijayaraj
experimental part, p. 3265 - 3271 (2012/05/20)
A series of 6,7,8,9-tetrahydro-5H-5-hydroxyphenyl-2-benzylidine-3- substituted hydrazino thiazolo (2,3-b) quinazolines have been synthesized to meet the structural requirements essential for anti-inflammatory and antinociceptive properties. The synthesized series of heterocycles, 6,7,8,9-tetrahydro-5H-5-hydroxyphenyl-2-benzylidine-3-substituted hydrazino thiazolo (2,3-b) quinazoline by the reaction of 6,7,8,9-tetrahydro-5H-5-hydroxy phenyl thiazolo (2,3-b) quinazolin-3(2H)-one with appropriate hydrazine hydrate and ketones/aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid as presented in Scheme 1. Their antinociceptive activity were evaluated by tailflick technique, anti-inflammatory was evaluated by carrageenan-induced paw edema test and their ulcerogenicity index determined by reported protocol. The compounds exhibited the lowest ulcer index (0.51 ± 1.63, 0.48 ± 1.28 and 0.50 ± 1.53, respectively. The 6,7,8,9-tetrahydro-5H-5-hydroxy phenylhydroxy-2-benzylidine-3-(N'-3- pentylidenehydrazino) thiazolo (2,3-b) quinazoline and 6,7,8,9-tetrahydro-5H-5- hydroxy phenyl-2-benzylidine-3-(N'-2-pentylidene- hydrazino) thiazolo (2,3-b) quinazoline exhibited the most potent antinociceptive and anti-inflammatory activities.
POLYMETHINE DYES BASED ON BENZOPYRYLIUM IONS
Makin, S. M.,Markina, T. A.,Boiko, I. I.
, p. 2182 - 2187 (2007/10/02)
A method is described for the synthesis of a series of benzopyrylium polymethine dyes by the acid cyclization of 2-hydroxystyryl polyenyl ketones, obtained by the successive crotonic condensation of aliphatic or alicyclic ketones initially with salicylaldehyde and its alkyl or halogen derivatives and then with aromatic aldehydes containing a p-methoxyphenyl or 9-alkylcarbazole fragment.The electronic absorption spectra of the new benzopyrylium dyes were studied.
