503590-22-5Relevant academic research and scientific papers
Highly substituted 2-amido-furans from rh(ll)-catalyzed cyclopropenations of ynamides
Li, Hongyan,Hsung, Richard P.
supporting information; experimental part, p. 4462 - 4465 (2009/12/24)
Rh(II)-catalyzed cyclopropenations of ynamides are described. Although an actual amido-cyclopropene intermediate may not be involved, these reactions provide a facile entry to highly substituted 2-amido-furans, thereby formerly constituting a [3 + 2] cycloaddition. An application of these de novo 2-amido-furans In N-tethered intramolecular [4 + 2] cycloadditions is also illustrated, leading to dihydroindoles and tetrahydroqulnolines
A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides
Frederick, Michael O.,Mulder, Jason A.,Tracey, Michael R.,Hsung, Richard P.,Huang, Jian,Kurtz, Kimberly C. M.,Shen, Lichun,Douglas, Christopher J.
, p. 2368 - 2369 (2007/10/03)
A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. Copyright
