503590-24-7Relevant academic research and scientific papers
Regioselective TfOH-mediated hydroamidation of ynamides with nitriles
Wang, Wan-Shu,Chen, Ping,Tang, Yu
, p. 2731 - 2739 (2017/04/14)
A new TfOH-mediated reaction of ynamides with nitriles as nucleophiles has been developed. The reaction works efficiently under mild reaction conditions to afford a new class of α-acylaminoenamides readily via the intermediacy of keteniminium ion. The reaction displays generality and a broad substrates scope. Additionally, the α-acylaminoenamides could be transformed to highly substituted pyridine, 4-aminopyrimidine or isoquinoline cores.
Copper-catalyzed alkynylation of amides with potassium alkynyltrifluoroborates: A room-temperature, base-free synthesis of ynamides
Jouvin, Kevin,Couty, Francois,Evano, Gwilherm
supporting information; experimental part, p. 3272 - 3275 (2010/10/21)
(Figure Presented) An efficient copper-mediated method for the coupling of potassium alkynyltrifluoroborates with nitrogen nucleophiles is reported. This reaction provides the first base-free and room-temperature synthesis of ynamides and allows for an easy preparation of these useful building blocks.
A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides
Frederick, Michael O.,Mulder, Jason A.,Tracey, Michael R.,Hsung, Richard P.,Huang, Jian,Kurtz, Kimberly C. M.,Shen, Lichun,Douglas, Christopher J.
, p. 2368 - 2369 (2007/10/03)
A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. Copyright
