503590-32-7Relevant academic research and scientific papers
A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides
Frederick, Michael O.,Mulder, Jason A.,Tracey, Michael R.,Hsung, Richard P.,Huang, Jian,Kurtz, Kimberly C. M.,Shen, Lichun,Douglas, Christopher J.
, p. 2368 - 2369 (2003)
A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. Copyright
Approach to Tertiary-Type β-Hydroxyl Carboxamides through Sc(OTf)3-Catalyzed Addition of Ynamides and Ketones
Liu, Yi-Wen,Mao, Zhuo-Ya,Nie, Xiao-Di,Si, Chang-Mei,Wei, Bang-Guo,Lin, Guo-Qiang
, p. 16254 - 16261 (2019/12/27)
An efficient approach to access functionalized tertiary-type β-hydroxyl carboxamides has been developed through Sc(OTf)3-catalyzed addition of ynamides and substituted ketones. Water was found to be an important reaction substrate, and the solvent was not needed in this process. A broad range of substituted ynamides and ketones was well applicable to the reaction with excellent chemical selectivities. Moreover, several chiral β-hydroxyl carboxamides 3j-3r were prepared with excellent regioselectivities and outstanding diastereoselectivities.
