503593-98-4

Upstream product

• 90-02-8 salicylaldehyde 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Downstream Products

• 1431151-88-0 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide 
• 1431152-28-1 (3-((3,5-bis(trifluoromethyl)phenyl)amino)-2,3-dihydrobenzofuran-2-yl)(pyrrolidin-1-yl)methanone 

Relevant academic research and scientific papers

Synthesis, biological activity, DNA binding and anion sensors, molecular structure and quantum chemical studies of a novel bidentate Schiff base derived from 3,5-bis(triflouromethyl)aniline and salicylaldehyde

Synthesis, biological activity, spectroscopic and crystallographic characterization and density functional theory (DFT) studies of the Schiff base 3,5-bis(triflouromethyl)aniline and salicylaldehyde are reported. It crystallizes as a monoclinic space group P21/c with a = 7.7814(3) ?, b = 26.8674(9) ?, c = 7.4520(2) ?, V = 1379.98(8), Z = 4, Dc = 1.6038 g cm-3, and μ = 0.156 mm-1. The molecular structure obtained from X-ray single-crystal analysis of the investigated compound in the ground state was compared using Hartree-Fock (HF) and density functional theory (DFT) with the functionals B3LYP and B1B95 using the 6-311++G(d,p) basis set. The antimicrobial activities of the compound were investigated for its minimum inhibitory concentration (MIC). The interaction of the Schiff base with calf thymus DNA was investigated using UV-visible spectra. The colorimetric response of the Schiff base receptors in DMSO was investigated before and after the addition of an equivalent amount of each anion to evaluate the anion recognition properties.

Formal [4+1] cycloaddition of camphor-derived sulfonium salts with aldimines: Enantioselective synthesis of 2,3-dihydrobenzofurans

An asymmetric formal [4+1] cycloaddition of camphor-derived sulfonium salts with aldimines has been described. The reaction allows for the efficient synthesis of trans-2,3-disubstituted-2,3-dihydrobenzofurans in moderate to good yields with >95:5 dr and u

Extensive spectral tuning of the proton transfer emission from green to red via a rational derivatization of salicylideneaniline

A series of salicylideneaniline derivatives 1a-1f were synthesized under mild condition in high yields, and characterized by 1H NMR, HRMS, UV-vis and emission spectra. In solid and aprotic solvents 1a-1f exist mainly as E conformers that posses