503606-59-5Relevant academic research and scientific papers
Co-Catalyzed Direct Regio- And Enantioselective Intermolecular γ-Amination of N-Acylpyrazoles
Bai, He-Yuan,Duan, Abing,Fu, Xin,Hao, Yu,Zhang, Shu-Yu
, p. 25 - 30 (2021)
A cobalt-catalyzed regio- and enantioselective γ-amination of β,γ-unsaturated N-acylpyrazoles that delivers the corresponding γ-amination products in good regio- and enantioselectivity has been established. Moreover, the nitrogen-containing compounds could be easily synthesized. DFT calculations have been provided to explain regio- and enantioselectivity for this γ-amination. The chiral γ-amination products were readily converted into the chiral γ-amino acid derivatives.
Synthetic method of chiral γ - amino acid and chiral γ - amino acid synthesized by adopting method (by machine translation)
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, (2020/09/16)
The invention relates to a synthesis method of chiral γ - amino acid and chiral γ - amino acid synthesized by adopting the method, wherein an intermediate compound I is synthesized by amination reaction under the action of a catalyst under the action of a catalyst under the action of the catalyst. Ni / H2 Reduction in the system, re-Boc and Boc2 O react to form the intermediate compound II, and the ester group protecting group is removed under basic conditions, namely, chiral γ - amino acid is synthesized. Compared with the prior art, the method has the advantages that the process is simple, γ - amination reaction of unsaturated amide is catalyzed by cheap metal chiral cobalt complex to synthesize the intermediate compound I, chiral γ - amino acid with a substituent γ position can be synthesized directly and efficiently, and a novel method is provided for asymmetric catalytic synthesis of chiral γ - amino acids. (by machine translation)
Synthesis and biological evaluation of pretubulysin and derivatives
Ullrich, Angelika,Herrmann, Jennifer,Mueller, Rolf,Kazmaier, Uli
experimental part, p. 6367 - 6378 (2011/03/21)
Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in the subnanomolar range towards various tumor cell lines. Its activity is only slightly less than those of the structurally more complex tubulysins. With a straig
Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo
Kokotos, George,Six, David A.,Loukas, Vassilios,Smith, Timothy,Constantinou-Kokotou, Violetta,Hadjipavlou-Litina, Dimitra,Kotsovolou, Stavroula,Chiou, Antonia,Beltzner, Christopher C.,Dennis, Edward A.
, p. 3615 - 3628 (2007/10/03)
The Group IVA cytosolic phospholipase A2 (GIVA PLA2) is a particularly attractive target for drug development because it is the rate-limiting provider of proinflammatory mediators. We previously reported the discovery of novel 2-oxoa
1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives
Hanessian, Stephen,Schaum, Robert
, p. 163 - 166 (2007/10/03)
Dianions derived from N-TFA and N-Boc γ-amino acid esters and amides undergo highly stereoselective α-alkylation reactions. The roles of HMPA, of the cation, the electrophile, and of steric factors were studied.
