503610-14-8

Basic information

• Product Name: 3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aS,4S)- (9CI)
• Synonyms: 3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aS,4S)- (9CI)
• CAS NO: 503610-14-8
• Molecular Formula: C22H32FNO2
• Molecular Weight: 361.498
• Mol File: 503610-14-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aS,4S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aS,4S)- (9CI)(503610-14-8)
• EPA Substance Registry System: 3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aS,4S)- (9CI)(503610-14-8)

Safety Data

• Hazardous Substances Data: 503610-14-8(Hazardous Substances Data)

Upstream product

• 503559-76-0 4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-nicotinic acid methyl ester 
• 618892-24-3 4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester 
• 503559-80-6 4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-pyridine-3-carbaldehyde 
• 618892-25-4 4-(2-benzyloxy-4-fluoro-phenyl)-5-formyl-2,6-diisopropyl-nicotinic acid methyl ester 
• 470717-47-6 dimethyl 2,6-diisopropyl-4-(2'-benzyloxy-4'-fluoro-phenyl)-3,5-pyridinedicarboxylate 
• 470717-49-8 dimethyl 2,6-diisopropyl-4-hydroxy-3,5-pyridine-dicarboxylate 
• 470717-52-3 dimethyl 2,6-diisopropyl-4-methoxy-3,5-pyridine-dicarboxylate 
• 470717-48-7 dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 503559-84-0 1-[4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-pyridin-3-yl]-ethanol 

Relevant articles and documents

Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists

Optimized substituent patterns in 4-aryl-pyridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1R)-hydroxyethyl] and a 2′-hydroxy group. Due to restricted rotation of the phenyl-pyridine bond, these analogues exist as four isomers. A diastereoselective methylcopper reaction was developed to facilitate the synthesis, and single isomers were isolated with activities in the range IC50=10-25 nM.