503631-25-2

Upstream product

• 85-44-9 phthalic anhydride 
• 56613-80-0 D-2-phenylglycinol 
• 205380-30-9 (R)-2-(2-hydroxy-1-phenylethyl)-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: Observation of stereoelectronic effects

Full details of a flexible approach to N-protected (R)-3-alkyl-isoindolin- 1-ones 13 via diastereoselective reductive-alkylation are described, with emphasis on the stereochemical outcome of the key diastereoselective reactions. Additional experiments allowed finding remarkable stereoelectronic effects on the reductive ring-opening reactions.