503631-77-4Relevant academic research and scientific papers
Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β
Garcia Collazo, Ana-Maria,Koehler, Konrad F.,Garg, Neeraj,Faernegardh, Mathias,Husman, Bolette,Ye, Liu,Ljunggren, Jan,Mellstroem, Karin,Sandberg, Johnny,Grynfarb, Marlena,Ahola, Harri,Malm, Johan
, p. 1240 - 1244 (2007/10/03)
Based on the examination of the crystal structure of rat TRβ complexed with 3,5,3′-triiodo-l-thyronine (2) a novel TRβ-selective indole derivative 6b was prepared and tested in vitro. This compound was found to be 14 times selective for TRβ over TRα in bi
IDOL DERIVATIVES AS NEW THYROID RECEPTOR AGONIST LIGANDS AND METHODS
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Page 26, (2010/02/05)
This invention relates to novel compounds of the general formula (I), which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor Beta and to methods of preparing such compound. In addition, a method is provided for p
Indole carboxylic acids as thyroid receptor ligands
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, (2008/06/13)
A compound of the formula wherein W, R1, R2, R3, R4, R5, R6, R7, R8 and R13 are as defined herein, useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, th
