50366-67-1Relevant academic research and scientific papers
Efficient synthesis of γ-keto sulfones by NHC-catalyzed intermolecular Stetter reaction
Bhunia, Anup,Yetra, Santhivardhana Reddy,Bhojgude, Sachin Suresh,Biju, Akkattu T.
supporting information; experimental part, p. 2830 - 2833 (2012/07/17)
The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon-carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.
