50369-39-6Relevant academic research and scientific papers
PYRIDOPYRIMIDINES AND METHODS OF THEIR USE
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, (2021/12/28)
Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.
Synthesis of Cyclic Azomethine Imines by Cycloaddition Reactions of N-Isocyanates and N-Isothiocyanates
Bongers, Amanda,Ranasinghe, Indee,Lemire, Philippe,Perozzo, Alyssa,Vincent-Rocan, Jean-Fran?ois,Beauchemin, André M.
, p. 3778 - 3781 (2016/08/16)
Various nitrogen-substituted iso(thio)cyanates engage in [3 + 2]-cycloaddition reactions to form azomethine imines containing triazolone, triazole-thione, and pyrazole-thione cores. First, iminoisothiocyanates are shown to undergo aminothiocarbonylation reactions with strained alkenes, and a comparison with recently reported reactions of iminoisocyanates highlights their reduced reactivity. In contrast, amino(thio)carbonylation reactions of imines with iminoisocyanates and iminoisothiocyanates proved more efficient, providing access to triazolone and triazole-thione cores. The dipole products can be converted to valuable heterocyclic cores through simple derivatization reactions.
2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents
Kane,Baron,Dudley,Sorensen,Staeger,Miller
, p. 2772 - 2777 (2007/10/02)
A series of 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones was evaluated for anticonvulsant activity. In general the members of this series were prepared by the alkaline crystalization of 1-aroyl-4-alkylsemicarbazides. The resulting 2-unsubstituted 3H-1,2,4-t
The Bis(tricyclohexylstannyl) Sulfide Thionation of 3H-1,2,4-Triazol-3-ones
Kane, John M.
, p. 912 - 914 (2007/10/02)
5-Aryl-2,4-dialkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones may be converted in 55-74percent yield to the corresponding 3H-1,2,4-triazole-3-thiones by using the combination bis(tricyclohexylstannyl) sulfide/boron trichloride.
Thermal Behaviour of 3-Phenyl-1,2,4-oxadiazol-5-ylhydrazines
Adembri, Giorgio,Camparini, Alfredo,Ponticelli, Fabio,Tedeschi, Piero
, p. 1703 - 1706 (2007/10/02)
Depending on the substitution on the hydrazine moiety, thermolysis of 3-phenyl-1,2,4-oxadiazol-5-ylhydrazines (1)-(5) gives variable amounts of 1-amino-Δ2-1,2,4-triazolin-5-ones (13) or (17), Δ2- or Δ3-1,2,4-triazolin-5-ones (12), (18), or (19), and the s-triazine (20).A possible mechanism accounting for the products and the effects is discussed.A diradical intermediate and a hydrogen transfer from the reaction medium are suggested on the basis of the effect of benzoyl peroxide on the reaction and on the behaviour of the hydrazines (1)-(4) towards catalytic hydrogenation.
