50372-82-2Relevant academic research and scientific papers
Tropane derivatives and method for their synthesis
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Page column 23, (2010/11/29)
A compound of formula (I) wherein R1-R6have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of f
Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters
Kozikowski, Alan P.,Araldi, Gian Luca,Prakash,Zhang, Mei,Johnson, Kenneth M.
, p. 4973 - 4982 (2007/10/03)
In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (DAT) through strategic modifications
Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3β-phenyltropane derivatives
Xu, Lifen,Kelkar, Shreekrishna V.,Lomenzo, Stacey A.,Izenwasser, Sari,Katz, Jonathan L.,Kline, Richard H.,Trudell, Mark L.
, p. 858 - 863 (2007/10/03)
A series of 2β-substituted 3β-phenyltropanes were synthesized as analogs of cocaine and tested in vitro for their ability to displace bound [3H]WIN 35,428 (2b) and inhibit dopamine uptake in rat caudate-putamen tissue. The analogs bound with hi
