503837-75-0Relevant academic research and scientific papers
Trypanocidal activity of conformationally restricted pentamidine congeners
Donkor, Isaac O.,Huang, Tien L.,Tao, Bin,Rattendi, Donna,Lane, Schennella,Vargas, Marc,Goldberg, Burt,Bacchi, Cyrus
, p. 1041 - 1048 (2003)
A series of conformationally restricted congeners of pentamidine in which the flexible pentyl bridge of pentamidine was replaced by trans-1,2-bismethylenecyclopropyl, phenyl, pyridinyl, piperazinyl, homopiperazinyl, and piperidinyl groups were synthesized
Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines
Huang, Tien L.,Zhang, Qian,White, Angele T.,Queener, Sherry F.,Bartlett, Marilyn S.,Smith, James W.,Donkor, Isaac O.
, p. 2087 - 2090 (2007/10/03)
A series of novel piperidine-linked aromatic diimidazolines (3-7) have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii drug, Pentamidine. These compounds significantly inhibited the growth of Pneumocystis carinii in culture at 1 μg/mL.
