503859-17-4Relevant academic research and scientific papers
The Synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H- pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors
Martin, Scott W.,Glunz, Peter,Beno, Brett R.,Bergstrom, Carl,Romine, Jeffrey L.,Scott Priestley,Newman, Makenzie,Gao, Min,Roberts, Susan,Rigat, Karen,Fridell, Robert,Qiu, Dike,Knobloh, Galina,Wang, Ying-Kai
supporting information; experimental part, p. 2869 - 2872 (2011/06/26)
Herein we report the identification and evaluation of a novel series of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid derivatives identified from a deannulation study performed on the reported benzimidazole NS5B inhibitor, 1. This resulted in
Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and its applications for biological imaging
Koide, Yuichiro,Urano, Yasuteru,Hanaoka, Kenjiro,Terai, Takuya,Nagano, Tetsuo
supporting information; experimental part, p. 5680 - 5682 (2011/06/18)
A far-red to near-infrared (NIR) fluorescence probe, MMSiR, based on Si-rhodamine, was designed and synthesized for sensitive and selective detection of HOCl in real time. MMSiR and its oxidized product SMSiR have excellent properties, including pH-indepe
Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109
Hirashima, Shintaro,Suzuki, Takayoshi,Ishida, Tomio,Noji, Satoru,Yata, Shinji,Ando, Izuru,Komatsu, Masakazu,Ikeda, Satoru,Hashimoto, Hiromasa
, p. 4721 - 4736 (2007/10/03)
Following the discovery of a new series of benzimidazole derivatives bearing a diarylmethyl group as inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (HCV NS5B RdRp), we extended the structure-activity relationship (SAR) study to analogue
NITROGEN-CONTAINING HETEROARYL DERIVATIVES
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Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
