504-73-4

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Dihydroisoxazoles are used as key structural components in the development of biologically active compounds. Their presence in various molecules contributes to their pharmacological properties, making them valuable in the creation of new drugs and therapeutic agents.
Used in Synthetic Organic Chemistry:
As synthons, 4,5-dihydroisoxazoles play a crucial role in the synthesis of complex organic molecules. Their capacity to mask other functional groups enables chemists to perform further functionalization of the ring, facilitating the development of a wide range of organic compounds with diverse applications.
Used in Chemical Research:
4,5-Dihydroisoxazoles serve as important model compounds in chemical research, allowing scientists to study their properties, reactivity, and potential applications in various fields, including materials science, catalysis, and environmental chemistry.

Chemical Reactivity

4,5-Dihydroisoxazoles having a proton at the C3-position easily undergo isomerization under the influence of a base to generate β-hydroxynitriles. These heterocycles can also be converted to the corresponding amino alcohols through reduction of internal oxime functionality. Apart from these reactions, the selective scission of the N-O bond under various conditions has also been reported.

Downstream Products

• 504-72-3 isoxazolidine 
• 288-14-2 ISOXAZOLE 

Relevant academic research and scientific papers

Epothilone derivatives and methods for making and using the same

The present invention relates to bicyclic compounds wherein one of the cyclic moieties is a 16-membered macrocycle and to methods for making and using these compounds. The present invention provides compounds of the formula wherein: R1, R2, and R3 are each independently hydrogen, methyl or ethyl; R4 is hydrogen, hydroxyl, fluoro, oxo, oximino, or NRR′ where R and R′ are independently hydrogen, C1-C10 aliphatic, aryl or alkylaryl; R5 is hydrogen, oxo, or C1-C10 aliphatic; R6 is hydrogen, hydroxyl, oxo, C1-C10 aliphatic, C1-C10 alkylester, or halide, or optionally R5 and R6 together form a carbon-carbon bond; R7 is hydrogen, methyl, ethyl, methoxy, or OH; X is fused substituted or unsubstituted heterocyclo; Y is substituted or unsubstituted heterocyclo; R9 is aryl or —CH═C(Me)-Aryl; and, W is O or NR8 where R8 is hydrogen, C1-C10 aliphatic, aryl or alkylaryl.

Crystalline roxifiban

The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x-ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.

Crystalline form of 4- [ 5-methyl-3-phenylisoxazol-4-yl ] benzenesulfonamide

A stable crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide is described. This crystal structure, designated Form B, is more stable, has favorable handling properties and is characterized by its melting point, x-ray and other physical characterizations.

Isoxazoline and isoxazole fibrinogen receptor antagonists

This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

Substituted isoxazolidines and isoxazolines as intermediates for delimopinal

The invention concerns intermediates having the formula STR1 wherein R is 2-propylpentyl optionally with one, two or three internal unsaturated bonds, or 2-substituted-2-propylpentyl optionally with one or two internal unsaturated bonds wherein the 2-substituent is a leaving group.

PHARMACEUTICALS, PHOSPHORUS-CONTAINING 2-ISOXAZOLINES AND ISOXAZOLES CONTAINED THEREIN

Pharmaceuticals containing or composed of at least one compound of the formula I and/or one of its physiologically tolerated salts where appropriate, where the compounds of the formula I can, where appropriate, be in the form of pure stereoisomers or mixtures thereof; formula I is: STR1 in which R. sup.1 =organic radical or halogen, A=C,C single or C,C double bond,n=0, 1 or 2, and STR2 R 2 and R 3 =H or optionally substituted aliphatic radical. The pharmaceuticals are suitable for the prophylaxis and/or treatment of diseases of the immune system, especially of tumors, infections and/or autoimmune diseases of the human or animal body and for use as adjuvants for vaccines.Some of the compounds of the formula I are new; the compounds can be prepared by special processes.

Preparation of isoxazolines and isoxazoles

A process for forming isoxazolines or isoxazoles by contacting, in the presence of base, a nitro compound, a cyclic anhydride and a dipolarophile. The dicarboxylic acid is readily regenerated to be again reused as the dehydrating agent of additional nitro compound.

Isoxazolines as intermediates to furans

Isoxazolines of the general formula II STR1 in which R1, R2, R3 and R4 are each unsubstituted or halogen-, haloalkyl-, alkoxy-, haloalkoxy-, nitro-, cyano-, dialkylphosphonyl- or alkoxycarbonyl-substituted alkyl, aryl, aralkyl, alkoxycarbonyl or dialkoxyphosphonyl, R2 and R4 are each also hydrogen and R3 is also hydroxyalkyl which is unblocked or blocked by a detachable protective group or is haloalkyl, X is hydrogen or a detachable protective group, are used to prepare furans.

Aryl-3-isoxazole benzoates as plant growth regulants and herbicides

2-(5-Aryl or substituted aryl-3-isoxazolyl) benzoic acids or benzoates, e.g., 2-[5-[3-(trifluoromethyl)phenyl]-3-isoxazolyl] benzoic acid, and to their method of use as herbicides and plant growth regulants as well as to agricultural chemical compositions