5040-18-6

Basic information

• Product Name: N-Acetyl-2'-O,3'-O,5'-O-triacetylcytidine
• Synonyms: N,2'-O,3'-O,5'-O-Tetraacetylcytidine;N-Acetyl-2'-O,3'-O,5'-O-triacetylcytidine
• CAS NO: 5040-18-6
• Molecular Formula: C₁₇H₂₁N₃O₉
• Molecular Weight: 411.36
• Mol File: 5040-18-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Acetyl-2'-O,3'-O,5'-O-triacetylcytidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-2'-O,3'-O,5'-O-triacetylcytidine(5040-18-6)
• EPA Substance Registry System: N-Acetyl-2'-O,3'-O,5'-O-triacetylcytidine(5040-18-6)

Safety Data

• Hazardous Substances Data: 5040-18-6(Hazardous Substances Data)

Upstream product

• 133120-44-2 N-(2-Oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-acetamide 
• 13035-61-5 1,2,3,5-tetraacetylribose 
• 108-24-7 acetic anhydride 
• 65-46-3 CYTIDINE 
• 3768-18-1 N-acetylcytidine 
• 121058-82-0 N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 121524-02-5 phenyl-(tri-O-acetyl-1-thio-ξ-D-riboside) 
• 18027-23-1 4-(N-trimethylsilylacetamido)-2-trimethylsiloxypyrimidine 

Downstream Products

• 3768-18-1 N-acetylcytidine 
• 109205-43-8 2-(2,4-dioxo-4,4-dihydropyrimidin-1(2H)-yl)-6-(hydroxymethyl)morpholine 
• 1024-99-3 5-iodouridine 
• 84500-33-4 2',3',5'-tri-O-acetyl-5-iodouridine 
• 139323-52-7 N-trit-U-morpholino 
• 65-46-3 CYTIDINE 
• 34597-52-9 1-(α-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide 
• 56787-28-1 2',3',5'-tri-O-acetylcytidine 
• 4105-38-8 Tri-O-acetyluridine 
• 2341-22-2 5-fluorocytidine 

Relevant articles and documents

PURINE AND PYRIMIDINE NUCLEOTIDES AS ECTO-5'-NUCLEOTIDASE INHIBITORS

Disclosed is a compound of formula (I), wherein Q, U, T, A, a, b, c, and n are as defined herein. Also disclosed are methods of inhibiting ecto?5'?nucleotidase, inhibiting suppression of an antitumor immune response, inhibiting tumor growth of a cancerous

A versatile synthesis of 5'-fenctionalized nucleosides through regioselective enzymatic hydrolysis of their peracetylated precursors

We describe a chemo-enzymatic synthesis of modified nucleosides through lipase-catalyzed hydrolysis of their peracetylated precursors. It was found from screening of a large number of substrates that these enzymesregioselectivities were affected by the sugar and the nucleobase structures. By selecting the best enzyme for each substrate in terms of activity and regioselectivity, we prepared a small library of differently monodeprotecled purine and pyrimidine nucleosides useful as intermediates for the synthesis of high-value nucleosides and mononucleotides. By this approach, the chemo-enzymatic preparation of doxifluridine (14) and uridine 5'-monophosphate (5'-UMP, 15) from peracetylated uridine 1 was carried out. Elimination of many of the processing stages associated with existing methods was achieved, and higher yields and products of increased purity were generated. Wiley-VCH Verlag GmbH & Co. KGaA.

Nucleic acid related compounds. 127. Selective N-deacylation of N,O-peracylated nucleosides in superheated methanol

Solutions of peracylated adenosine, cytidine, and related nucleoside derivatives undergo selective N-deacylation upon heating at elevated temperatures (oil bath ≥ 105 °C) in methanol. An increase in the bulk of the N-acyl group has little effect on the rate of N-deacylation but increases the N/O selectivity ratio. Extended heating is required for N-deacylation with arylcarboxylic acid derivatives. Contamination with acidic or basic reagent residues is avoided.