50425-14-4

Basic information

• Product Name: Benzoyl chloride, 2-chloro-6-nitro-
• CAS NO: 50425-14-4
• Molecular Formula: C7H3Cl2NO3
• Molecular Weight: 220.012
• Mol File: 50425-14-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-chloro-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-chloro-6-nitro-(50425-14-4)
• EPA Substance Registry System: Benzoyl chloride, 2-chloro-6-nitro-(50425-14-4)

Safety Data

• Hazardous Substances Data: 50425-14-4(Hazardous Substances Data)

Upstream product

• 5344-49-0 2-chloro-6-nitrobenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 20895-88-9 (2-Chlor-6-nitro-benzoyl)-malonsaeurediethylester 
• 1258291-98-3 2-chloro-6-nitro-N-(pyridin-4-yl)benzamide 
• 1365990-80-2 3-chloro-2-[7-fluoro-4-(6-hydroxymethyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-benzonitrile 
• 1365992-91-1 2-(4-bromo-7-fluorothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile 
• 1365992-90-0 3-chloro-2-(4-chloro-7-fluorothiazolo[5,4-c]pyridin-2-yl)-benzonitrile 
• 1365992-89-7 3-chloro-2-(7-fluoro-5-oxythiazolo[5,4-c]pyridin-2-yl)-benzonitrile 
• 1365992-86-4 2-(2-chloro-6-nitrophenyl)-7-fluorothiazolo[5,4-c]pyridine 
• 1365992-85-3 2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzimidoyl chloride 
• 1365990-79-9 3-chloro-2-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-benzonitrile 
• 1365992-83-1 2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 1365992-84-2 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 80563-87-7 2-chloro-6-nitro-benzoic acid methyl ester 

Relevant articles and documents

SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the a

Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors

Compound 1 was identified by high throughput screening as a novel, potent, non-amidine factor Xa inhibitor with good selectivity against thrombin and trypsin. A series of modifications of the three aromatic groups of 1 was investigated. Substitution of chlorine or bromine for fluorine on the aniline ring led to the discovery of subnanomolar factor Xa inhibitors. Positions on the anthranilic acid ring that can accommodate further substitution were also identified.