50425-14-4

Upstream product

• 5344-49-0 2-chloro-6-nitrobenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1365990-80-2 3-chloro-2-[7-fluoro-4-(6-hydroxymethyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-benzonitrile 
• 1365992-91-1 2-(4-bromo-7-fluorothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile 
• 1365992-90-0 3-chloro-2-(4-chloro-7-fluorothiazolo[5,4-c]pyridin-2-yl)-benzonitrile 
• 1365992-89-7 3-chloro-2-(7-fluoro-5-oxythiazolo[5,4-c]pyridin-2-yl)-benzonitrile 
• 1365992-86-4 2-(2-chloro-6-nitrophenyl)-7-fluorothiazolo[5,4-c]pyridine 
• 1365992-85-3 2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzimidoyl chloride 
• 1365990-79-9 3-chloro-2-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-benzonitrile 
• 1365992-83-1 2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 1365992-84-2 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 20895-88-9 (2-Chlor-6-nitro-benzoyl)-malonsaeurediethylester 
• 172217-16-2 ethyl 2-chloro-6-nitrobenzoate 

Relevant academic research and scientific papers

SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the a

Anthranilic acid derivatives as nuclear receptor modulators - Development of novel PPAR selective and dual PPAR/FXR ligands

Nuclear receptors, especially the peroxisome proliferator activated receptors (PPARs) and the farnesoid X receptor (FXR) fulfill crucial roles in metabolic balance. Their activation offers valuable therapeutic potential which has high clinical relevance w

Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors

Compound 1 was identified by high throughput screening as a novel, potent, non-amidine factor Xa inhibitor with good selectivity against thrombin and trypsin. A series of modifications of the three aromatic groups of 1 was investigated. Substitution of chlorine or bromine for fluorine on the aniline ring led to the discovery of subnanomolar factor Xa inhibitors. Positions on the anthranilic acid ring that can accommodate further substitution were also identified.

4-Hydroxy-1,2-Benzisothiazol-3(2H)-one-1,1-dioxides and salts thereof

Compounds of the formula STR1 wherein R1 is hydrogen or hydroxyl, and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as sweetening agents.