504399-94-4

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 14727-23-2 6-methyl-2-(4-methylphenyl)pyrimidin-4-one 
• 79382-77-7 4-chloro-6-methyl-2-(4-methylphenyl)pyrimidine 
• 141-43-5 ethanolamine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists

Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.