5044-21-3

Usage

Uses

Used in Food and Beverage Industry:
Ethyl 2,5-dimethylpyrrole-1-acetate is used as a flavoring agent to impart a fruity, berry-like aroma and taste to various products. Its unique flavor profile enhances the sensory experience of food and beverages, making them more appealing to consumers.
Used in Perfumes and Personal Care Products:
In the fragrance industry, Ethyl 2,5-dimethylpyrrole-1-acetate is used as a fragrance ingredient. Its sweet, fruity, and floral scent contributes to the overall aroma profile of perfumes and personal care products, providing a pleasant and attractive scent that enhances the consumer's experience.

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 110-13-4 2,5-hexanedione 

Downstream Products

• 1312717-66-0 methyl 2-(2,5-dimethyl-3-phenyl-4-(2-(pyrrolidin-1-ylsulfonyl)phenylthio)-1H-pyrrol-1-yl)acetate 
• 1312718-23-2 ethyl 2-(3-iodo-2,5-dimethyl-4-(2-(pyrrolidin-1-ylsulfonyl)phenylthio)-1H-pyrrol-1-yl)acetate 
• 1312718-21-0 ethyl 2-(2,5-dimethyl-3-(2-(morpholinosulfonyl)benzoyl)-1H-pyrrol-1-yl)acetate 

Relevant academic research and scientific papers

Synthesis method of 1-aminomethyl-1-cyclopropanol

The invention discloses a synthetic method of 1-aminomethyl-1-cyclopropanol. The synthetic method comprises the following steps: adding a compound C00 into an aqueous potassium carbonate solution to form a first solution; adding an aqueous solution of C01 into the first solution for a reaction; combining organic phases, carrying out cleaning with saline water, and performing drying, filtering andconcentrating to obtain a compound C02; dissolving the compound C02 in tetrahydrofuran to form a second solution; adding tetraisopropyl titanate into the second solution to form a third solution; adding an ethyl magnesium bromide solution into the third solution for a reaction; adding an aqueous ammonium chloride solution into the solution for a quenching reaction; combining organic layers to obtain a compound C03; dissolving the compound C03 into an absolute ethyl alcohol solution to form a fourth solution; adding a sodium hydroxide solution into the fourth solution; adding a hydroxylamine hydrochloride solution into the fourth solution to form a fifth solution; and adding a sodium hydroxide solution into the fifth solution until the pH value is 6-7, and carrying out distilling to removea water phase, thereby obtaining the product, i.e., 1-aminomethyl-1-cyclopropanol. In this way, palladium hydroxide is not used as a catalyst, and synthesis cost is reduced.

CRTH2 MODULATORS AND PREPARATION THEREOF

The present invention relates to processes and intermediates for the preparation of compounds useful as CRTH2 antagonists. Compounds prepared by the processes of the invention are of Formula (AI), (All) and Compound (I).

CRTH2 MODULATORS

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I: