50440-84-1Relevant academic research and scientific papers
Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists
Pieters, Serge,McGowan, David,Herschke, Florence,Pauwels, Frederik,Stoops, Bart,Last, Stefaan,Embrechts, Werner,Scholliers, Annick,Mostmans, Wendy,Van Dijck, Kris,Van Schoubroeck, Bertrand,Thoné, Tine,De Pooter, Dorien,Fanning, Gregory,Rosauro, Mari Luz,Khamlichi, Mourad Daoubi,Houpis, Ioannis,Arnoult, Eric,Jonckers, Tim H.M.,Raboisson, Pierre
supporting information, p. 711 - 719 (2018/01/27)
The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure–activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the potent agonist 48. Pharmacokinetic and pharmacodynamic studies highlighted 48 as an orally available endogenous interferon (IFN-α) inducer in mice.
QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
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Paragraph 0055; 0063, (2014/03/25)
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
HETEROCYCLIC SUBSTITUTED 2-AMINO-QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
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Page/Page column 9; 11, (2014/06/11)
This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
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Page/Page column 12, (2012/12/13)
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.
