50441-36-6Relevant academic research and scientific papers
Synthetic and cytotoxic and antimicrobial activity studies on annomuricatin B
Dahiya, Rajiv,Maheshwari, Monika,Yadav, Rakesh
experimental part, p. 237 - 244 (2009/06/17)
The first total synthesis of annomuricatin B (8) is described via coupling of the tripeptide Boc-L-asparaginyl(benzhydryl)-L-alanyl-L-tryptophan-OH and the tetrapeptide L-leucyl-glycyl-L-thryl-L-proline-OMe followed by cyclization of the linear heptapeptide fragment. On pharmacological investigation, it was observed that the cycloheptapeptide 8 displays moderate cytotoxicity against Datton's lymphoma ascites and Ehrlich's ascites carcinoma cell lines with cytotoxic inhibitory concentration (50%) values of 11.6 and 14.1 μM, in addition to potent antidermatophyte activity against Trichophyton mentagrophytes and Microsporum audouinii with a minimum inhibitory concentration of 6 μg mL-1. Moreover, Gram-negative bacteria and Candida albicans were found to be moderately sensitive towards the newly synthesized peptide.
Synthesis, characterization and biological evaluation of cyclic peptides: Viscumamide, yunnanin A and evolidine
Poojary, Boja,Belagali
, p. 1313 - 1320 (2008/02/08)
Three biologically active cyclic peptides, viscumamide, yunnanin A and evolidine were synthesized and the structures were established on the basis of analytical, IR, NMR and mass spectral data. These newly synthesized cyclic peptides were evaluated for an
