504438-12-4

Upstream product

• 681425-42-3 6,6-dibromo-3-azabicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester 
• 504438-13-5 benzyl (1α,5α,6α)-6-acetoxy-3-azabicyclo[3.1.0]hexan-3-ylcarboxylate 
• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 

Downstream Products

• 504438-14-6 benzyl (1α,5α,6α)-6-t-butyldimethylsilyloxy-3-azabicyclo[3.1.0]hexan-3-ylcarboxylate 
• 681425-46-7 {4-[(1α,5α,6α)-6-(tert-butyldimethylsilanyloxy)-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}carbamic acid benzyl ester 
• 681425-45-6 (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane 
• 681425-47-8 4-[(1S,5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-aza-bicyclo[3.1.0]hex-3-yl]-3,5-difluoro-phenylamine 
• 681425-44-5 (1α,5α,6α)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexan-1-ol 

Relevant academic research and scientific papers

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has become an

ANTIMICROBIAL [3.1.0] BICYCLIC OXAZOLIDINONE DERIVATIVES

The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them,

Bicyclo[3,1,0]hexane containing oxazolidinone antibioytics and derivatives thereof

Oxazolidinones having a bicyclic[3.1.0] hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fa