504440-55-5Relevant academic research and scientific papers
Synthesis and cytotoxicity of 3-(hetarylthio)-1-propynyl-(trimethyl)silanes
Abele,Abele,Rubina,Dzenitis,Arsenyan,Shestakova,Nesterova,Domracheva,Popelis,Grinberga,Lukevics
, p. 867 - 872 (2002)
We have developed a two-step method for synthesis of 3-(hetarylthio)-1-propynyl(trimethyl)silanes from thiols in a phase-transfer catalysis system HC≡CCH2Br-solid K2CO3-18-crown-6-toluene followed by reaction with n-BuLi-Me3SiCl in ether or THF. We have observed that 3-[1,3-bis(trimethylsilyl)-2-propynyl] thioindole displays high cytotoxicity in HT-1080 and MG-22A tumor cell lines.
