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General Description

2-<(2-Methoxyphenyl)oxymethyl>benzoic acid, also known as MOBA, is a chemical compound with the molecular formula C15H14O5. It is a derivative of benzoic acid and contains a benzoate group attached to a methoxyphenyl group through an oxymethyl linker. MOBA has been identified as an inhibitor of the sirtuin family of proteins, which are involved in regulating a variety of cellular functions, including aging, metabolism, and stress resistance. 2-<(2-Methoxyphenyl)oxymethyl>benzoic acid shows potential in research aimed at developing treatments for conditions such as metabolic disorders, neurodegenerative diseases, and cancer. Overall, 2-<(2-Methoxyphenyl)oxymethyl>benzoic acid has garnered interest in the scientific community due to its unique chemical structure and potential therapeutic applications.

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 13052-77-2 sodium 2-methoxyphenolate 
• 90-05-1 2-methoxy-phenol 

Relevant academic research and scientific papers

Iron(II) promoted direct synthesis of dibenzo[b,e]oxepin-11(6H)-one derivatives with biological activity. A short synthesis of doxepin

A novel and efficient synthesis of dibenzo[b,e]oxepin-11(6H)-ones by direct intramolecular ortho-acylation from readily available 2-(phenoxymethyl)benzoic acids was developed. The method takes advantage of a newly developed cooperative system consisting of sustainable FeCl2 and Cl2CHOCH3 as the key components. This methodology is compatible with a wide variety of functional groups in good to excellent yields and high regioselectivity. The synthetic application of new protocol was extended to the synthesis of known tricyclic drug doxepin as well as a small library of oxepin based derivatives. For the first time, the obtained dibenzo[b,e]oxepinone derivatives were evaluated for their biological activities on the free-living nematode Caenorhabditis elegans as an effective and cost-efficient model system for anthelmintic discovery.

Synthesis and biological activity of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepin derivatives, potential agents for the treatment of cerebrovascular disorders

A series of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepins and related compounds were synthesized and evaluated for their protective activities against complete ischemia, normobaric hypoxia, lipidperoxidation and convulsion. Structure-activity relationship studies of this series led to the finding of (E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-(3-phenyl-2-prop enyl)piperazine dimaleate (50), AJ-3941 with the most appropriate property for combined pharmacological activities. Compound 50 also shows an inhibitory effect against cerebral edema as well when orally given to rats.