50473-32-0Relevant academic research and scientific papers
First synthesis of 2-phosphonylated quinoxaline 1,4-dioxides: An extension to the Beirut reaction
Dahbi, Samir,Methnani, Ebtissem,Bisseret, Philippe
scheme or table, p. 5516 - 5520 (2010/10/21)
An extension of the Beirut reaction for the preparation of the first members of the 2-phosphonylated quinoxaline 1,4-dioxide series is described. Contrary to their carboxylated equivalents, preparation of these new compounds could not be achieved under basic conditions but required the use of powdered molecular sieves. Good and reproducible yields were obtained only when the initial suspension in THF was transformed into a pasty film by slow evaporation of ca. 90% of the initial solvent volume.
A new efficient route for the formation of quinoxaline N-oxides and N,N′-dioxides using HOF·CH3CN
Carmeli, Mira,Rozen, Shlomo
, p. 5761 - 5765 (2007/10/03)
HOF·CH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N′-dioxides in very good yields under mild conditions and short reaction times.
