5048-34-0

Basic information

• Product Name: 8-Nonenenitrile
• Synonyms: 8-Nonenenitrile
• CAS NO: 5048-34-0
• Molecular Formula: C₉H₁₅N
• Molecular Weight: 137.23
• Mol File: 5048-34-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 233.7°C at 760 mmHg
• Flash Point: 101.1°C
• Appearance: /
• Density: 0.828g/cm³
• Vapor Pressure: 0.055mmHg at 25°C
• Refractive Index: 1.437
• CAS DataBase Reference: 8-Nonenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Nonenenitrile(5048-34-0)
• EPA Substance Registry System: 8-Nonenenitrile(5048-34-0)

Safety Data

• Hazardous Substances Data: 5048-34-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H15N/c1-2-3-4-5-6-7-8-9-10/h2H,1,3-8H2

Upstream product

• 13050-09-4 8-oxooctanenitrile 
• 23895-60-5 tri-n-butylstannyldibromomethane 
• 1782-03-2 (E)-1-nitrocyclooctene 
• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 
• 2695-48-9 8-Bromo-1-octene 
• 143-33-9 sodium cyanide 
• 27936-01-2 5-Hexenylquecksilberbromid 
• 107-13-1 acrylonitrile 
• 773837-37-9 sodium cyanide 
• 39770-04-2 8-nonen-1-al 
• 13175-44-5 oct-7-en-1-ol 

Downstream Products

• 71819-29-9 methyl 4-(benzyloxy)-2-methoxy-6-(7-octenyl)benzoate 
• 102342-68-7 2,4-dihydroxy-6-(7-octenyl)benzoic acid, methyl ester 
• 102342-69-8 4-Benzyloxy-2-hydroxy-6-oct-7-enyl-benzoic acid methyl ester 
• 1325235-97-9 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate 
• 1325235-98-0 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl 2-(cyclohexanecarboxamido)acetate 
• 1325235-99-1 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-acetamidopropanoate 
• 1325236-01-8 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclopentanecarboxamido)propanoate 
• 1325236-02-9 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)-3-methylbutanoate 
• 1325236-03-0 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)-4-methylpentanoate 
• 1325236-04-1 (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)-3-phenylpropanoate 
• 1325235-70-8 N-(3-(3-hydroxypropyl)-5-methoxyphenyl)non-8-enamide 
• 1325235-75-3 (S,E)-N-(3-(7-hydroxy-4-methyldeca-3,9-dien-1-yl)-5-methoxyphenyl)non-8-enamide 
• 1325235-76-4 (R)-(R,E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl 2-(cyclohexanecarboxamido)propanoate 
• 1325235-78-6 (4R,7Z)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2R)-2-(cyclohexanecarboxamido)propanoate 

Relevant articles and documents

SYNTHESIS OF STRAIGHT-CHAIN LEPIDOPTERAN PHEROMONES THROUGH ONE- OR TWO- CARBON HOMOLOGATION OF FATTY ALKENES

Methods for the preparation of alkenes including insect pheromones are described. The methods include homologation reactions employing reagents such as 1,3-diesters, epoxides, cyanoacetates, and cyanide salts for elongation of starting materials and intermediates by one or two carbon atoms. The alkenes include insect pheromones useful in a number of agricultural applications.

Monoenomycin: A simplified trienomycin A analogue that manifests anticancer activity

Macrocyclic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's "rule of 5", these compounds often demonstrate superior druglike physicochemical and pharmacokinetic attributes when compared to their acyclic counterparts. However, the elaborate structural architectures of such molecules require rigorous synthetic investigation that complicates analogue development and their application to drug discovery programs. To circumvent these limitations, a conformation-based approach using limited structure-activity relationships and molecular modeling was implemented to design simplified analogues of trienomycin A, in which the corresponding analogues could be prepared in a succinct manner to rapidly identify essential structural components necessary for biological activity. Trienomycin A is a member of the ansamycin family of natural products that possesses potent anticancer activity. These studies revealed a novel trienomycin A analogue, monoenomycin, which manifests potent anticancer activity.

Scope of the chromium(II)-mediated synthesis of E-alkenylstannanes from aldehydes and Bu3SnCHBr2

The synthesis of E-alkenylstannanes from aldehydes and a mixture of Bu3SnCHBr2, LiI and CrCl2 is described. A mechanism is proposed to account for the alkene geometry in chromium(II)-mediated alkene synthesis which involves stereoselective addition by a gem-dichromium reagent to an aldehyde followed by a stereospecific elimination step.