50508-60-6 Usage
Uses
Used in Pharmaceutical Industry:
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene is used as a key intermediate in the synthesis of Etizolam, an essential sedative hypnotic and antidepressant drug. Its role in the production of this medication is vital for addressing mental health concerns and providing relief to patients suffering from anxiety and depression.
Additionally, the compound's derivative, the 2-amino-3-(p-chlorobenzoyl) thiophene scaffold, is used as a pharmacophore for identifying small molecules acting as allosteric modulators at the adenosine A1 receptor. This application is crucial for the development of novel therapeutic agents targeting the adenosine A1 receptor, which plays a role in various physiological processes and disease conditions.
Used in the Preparation of Thienylamide Derivatives:
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene is also utilized in the preparation of thienylamide derivatives, which serve as cholecystokinin inhibitors. These inhibitors are essential in the treatment of various gastrointestinal disorders and conditions related to the regulation of pancreatic enzyme secretion and gut motility. 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene's role in the synthesis of these derivatives highlights its importance in the development of therapeutic agents for gastrointestinal health.
References
Kai, Yong Mao, et al. "An Improved Synthesis of Etizolam." Journal of Southwest University of Science & Technology ?(2014).
Romagnoli, R, et al. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study..Longing for the end. Macmillan, 2015:185–204.
Check Digit Verification of cas no
The CAS Registry Mumber 50508-60-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,5,0 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 50508-60:
(7*5)+(6*0)+(5*5)+(4*0)+(3*8)+(2*6)+(1*0)=96
96 % 10 = 6
So 50508-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H12ClNOS/c1-2-8-7-10(13(15)17-8)12(16)9-5-3-4-6-11(9)14/h3-7H,2,15H2,1H3
50508-60-6Relevant academic research and scientific papers
THE SYNTHESIS OF THIENOTRIAZOLOTHIAZEPINES
Nagaoka, Hitoshi,Hara, Hiromu,Mase, Toshiyasu
, p. 1241 - 1244 (2007/10/02)
Some derivatives of thienotriazolothiazepine, a novel heteroazepine, were synthesized.These compounds showed anti-PAF activity.
