505085-76-7

Upstream product

• 132652-65-4 tert-butyl 2,2-dimethyl-4-[(E)-2-phenylethenyl]-1,3-oxazolane-3-carboxylate 
• 132639-34-0 tert-Butyl (E,4S)-2,2-dimethyl-4-(2'-phenylvinyl)-3-oxazolidine-3-carboxylate 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 98184-95-3 (E)-4-phenylbut-3-ene-1,2-diol 

Downstream Products

• 505085-77-8 (2R,1'R)-4-phenyl-2-(1-phenylbut-3-enylamino)but-3-en-1-ol 
• 505085-84-7 (2R,1'R)-2-(1-cyclohexylbut-3-enylamino)-4-phenylbut-3-en-1-ol 
• 505085-96-1 (5R,8aR)-5-cyclohexyl-4,5,6,8a-tetrahydroxazolidino[3,4-a]pyridin-3-one 
• 505085-94-9 (5R,8aR)-5-phenylethyl-4,5,6,8a-tetrahydroxazolidino[3,4-a]pyridin-3-one 
• 652539-07-6 (4R,1'S)-3-(1-dodecylbut-3-enyl)-4-styryloxazolidin-2-one 
• 652539-06-5 (2R,1'S)-2-(1-dodecylbut-3-enylamino)-4-phenylbut-3-en-1-ol 
• 505085-92-7 (4R,1'R)-3-(1-cyclohexylbut-3-enyl)-4-styryloxazolidin-2-one 
• 505085-90-5 (4R,1'S)-3-(1-phenylethylbut-3-enyl)-4-styryloxazolidin-2-one 
• 505085-91-6 (4R,1'S)-3-(1-hexylbut-3-enyl)-4-styryloxazolidin-2-one 
• 505085-82-5 (2R,1'S)-4-phenyl-2-(1-phenylethylbut-3-enylamino)but-3-en-1-ol 
• 505085-83-6 (2R,1'S)-2-(1-hexylbut-3-enylamino)-4-phenylbut-3-en-1-ol 
• 505085-79-0 (4R,1'R)-3-(1-phenylbut-3-enyl)-4-styryloxazolidin-2-one 
• 505085-93-8 (4R,1'R)-3-(1-isopropylbut-3-enyl)-4-styryloxazolidin-2-one 
• 505085-85-8 (2R,1'R)-2-(1-isopropylbut-3-enylamino)-4-phenylbut-3-en-1-ol 

Relevant academic research and scientific papers

The synthesis of chiral β-aryl-α,β-unsaturated amino alcohols via a Pd-catalyzed asymmetric allylic amination

Chiral β-aryl-α,β-unsaturated amino alcohols were synthesized via a Pd-catalyzed asymmetric allylic amination of 4-aryl-1,3-dioxolan-2-one using planar chiral 1,2-disubstituted ferrocene-based phosphinooxazolines as ligands. Under the optimized reaction conditions, a series of substrates were examined and the products were obtained in good to excellent yields (up to 92%) and enantioselectivities (up to 98% ee) under mild reaction conditions. The desired products were determined to be of (R)-configuration and could subsequently be transformed into compounds with interesting biological activity using simple transformations.

A Novel Route to Chiral trans-6-Alkyl-2-hydroxymethyl-1,2,5,6-tetrahydropyridines by Allylation of Chiral Imines and Ring-Closing Metathesis - Total Synthesis of (-)-3-epi-Deoxoprosopinine

A novel route to enantiomerically pure trans-6-alkyl-2-hydroxymethyl-1,2,5,6-tetrahydropyridines is reported in five steps from Garner's aldehyde with overall yields higher than 35%. This strategy is based on the allylation of chiral imino alcohols formed

Efficient access to chiral trans-2,6-dialkyl-1,2,5,6-tetrahydropyridines via allylation of chiral imines and ring-closing metathesis

Enantiomerically pure trans-2,6-dialkyl-1,2,5,6-tetrahydropyridines are synthesized in five steps from Garner's aldehyde in 37-44% overall yield. This strategy is based on the allylation of chiral iminoalcohols formed in situ followed by a ring-closing metathesis.

A short and efficient synthesis of phytosphingosines using asymmetric dihydroxylation

A short synthesis of the phytosphingosine derivatives and their stereoisomers by using asymmetric dihydroxylation of the optically active olefins derived from L-serine is described.