505085-80-3

Upstream product

• 505085-77-8 (2R,1'R)-4-phenyl-2-(1-phenylbut-3-enylamino)but-3-en-1-ol 
• 505085-79-0 (4R,1'R)-3-(1-phenylbut-3-enyl)-4-styryloxazolidin-2-one 

Relevant academic research and scientific papers

A Novel Route to Chiral trans-6-Alkyl-2-hydroxymethyl-1,2,5,6-tetrahydropyridines by Allylation of Chiral Imines and Ring-Closing Metathesis - Total Synthesis of (-)-3-epi-Deoxoprosopinine

A novel route to enantiomerically pure trans-6-alkyl-2-hydroxymethyl-1,2,5,6-tetrahydropyridines is reported in five steps from Garner's aldehyde with overall yields higher than 35%. This strategy is based on the allylation of chiral imino alcohols formed

Efficient access to chiral trans-2,6-dialkyl-1,2,5,6-tetrahydropyridines via allylation of chiral imines and ring-closing metathesis

Enantiomerically pure trans-2,6-dialkyl-1,2,5,6-tetrahydropyridines are synthesized in five steps from Garner's aldehyde in 37-44% overall yield. This strategy is based on the allylation of chiral iminoalcohols formed in situ followed by a ring-closing metathesis.