505087-28-5

Upstream product

• 52805-36-4 4-benzyloxybenzonitrile 
• 55899-02-0 3-methyl-N-aminopyridinium mesitylenesulfonate 

Downstream Products

• 1308247-12-2 8-methyl-2-[4-(2-morpholino-4-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine 
• 1308247-09-7 8-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine 
• 1308247-11-1 8-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine 
• 898533-78-3 2-[4-(2-bromoethoxy)phenyl]-8-methyl[1,2,4]triazolo[1,5-a]pyridine 
• 898533-76-1 4-(8-methyl[1,2,4]triazolo[1,5-a]pyridin-2-yl)phenol 

Relevant academic research and scientific papers

Synthesis and antitumor activities of 2-(substituted)phenyl-1,2,4- triazolo[1,5-a]pyridines

(Chemical Equation Presented) Twenty-three 2-(substituted)phenyl-1,2,4- triazolo[1,5-a]pyridines have been synthesized by cyclo-additison reaction between N-amino methylpyridinium mesitylenesulfonates and substituted benzonitriles under the presence of po

Synthesis and antifungal activity of 2-aryl-1,2,4-triazolo[1,5-a]pyridine derivatives

A series of novel antifungal triazole derivatives 2-aryl-1,2,4-triazolo[1, 5-a]pyridine 9a-m were synthesized and tested in vitro for their growth inhibitory activities against C. albicans and T. rubrum. The MIC values indicate that the activities of three compounds were superior or comparable to fluconazole against both tested fungi, worthy of further investigation of its antifungal activities.

Regioselection in 1,3-dipolar cycloadditions of 3-methylpyridine N-imide to aromatic carbonitriles. Synthesis of 2-aryl-8-methyl[1,2,4]triazolo [1,5-a]pyridines

1-Amino-3-methylpyridinium mesitylenesulfonate (3) reacts with aromatic nitriles in the presence of potassium hydroxide, undergoing 1,3-dipolar cycloaddition followed by elimination of H2 to give 2-aryl-8-methyl[1,2,4]triazolo[1,5-a]pyridines as the major products, rather than the 6-methyl isomers.