5051-67-2 Usage
Description
(2E)-2-(4-chlorobenzylidene)-1,1,1-trimethylhydrazinium is a hydrazine derivative with the molecular formula C12H18ClN2. It features a 4-chlorobenzylidene group attached to a trimethylhydrazinium moiety, and is a liquid at room temperature. This chemical compound is of interest for its potential applications in various fields.
Uses
Used in Organic Synthesis:
(2E)-2-(4-chlorobenzylidene)-1,1,1-trimethylhydrazinium is used as a reactant in organic synthesis for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2E)-2-(4-chlorobenzylidene)-1,1,1-trimethylhydrazinium is utilized in research for the development of new pharmaceuticals. Its chemical properties and potential biological activity contribute to its use in the design and synthesis of novel drug candidates.
Used in Medicine:
Due to its potential biological activity, (2E)-2-(4-chlorobenzylidene)-1,1,1-trimethylhydrazinium may have applications in the field of medicine. While further research is needed to fully understand its therapeutic potential, it holds promise for future medicinal applications, particularly if its biological properties can be harnessed effectively.
Check Digit Verification of cas no
The CAS Registry Mumber 5051-67-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,5 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5051-67:
(6*5)+(5*0)+(4*5)+(3*1)+(2*6)+(1*7)=72
72 % 10 = 2
So 5051-67-2 is a valid CAS Registry Number.
5051-67-2Relevant articles and documents
Elimination Reactions of Hydrazonium Salts: Experimental and Theoretical Evidence for a Large Stereoelectronic Effect of Nitrogen
Nguyen, Minh Tho,Clarke, Leo F.,Hegarty, Anthony F.
, p. 6177 - 6183 (2007/10/02)
Elimination of trimethylamine from hydrazonium salts (8, R = Me) is promoted by base (methoxide ion in methanol).The mechanism is characterized as E2 as shown by substituent effects (ρ = +2.57), Broensted coefficients, a primary kinetic isotope effect (kH/kD = 2.10), and solvent effects.Variation in the leaving group (8, R = arylmethyl) shows that N-N bond cleavage is less well advanced in the transition state than C-H bond breaking.The elimination to give the nitrile is syn-periplanar and, using the phthalazinium salt 4 as a model for the anti elimination, an anti/syn ratio of ca. 102 is found.The reactions have been modelled using ab initio methods with the transition structures located at the HF/3-21G level and relative energies computed using the MP2/6-31G* method.Using both H2O and NH3 as model bases to induce elimination on +, the calculated energy for anti elimination is lower (in the range 11-13 kcal mol-1) than that for syn elimination.The implications of the results for the ease of formation of nitriles from aldehydes via the hydrazonium salt route are discussed.
