5052-95-9

Basic information

• Product Name: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one
• Synonyms: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one;1-oxa-3,8-diazaspiro[4.5]decan-2-one(SALTDATA: HCl)
• CAS NO: 5052-95-9
• Molecular Formula: C₇H₁₂N₂O₂
• Molecular Weight: 156.18238
• Mol File: 5052-95-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one(5052-95-9)
• EPA Substance Registry System: 1-Oxa-3,8-diazaspiro(4.5)decan 2-one(5052-95-9)

Safety Data

• Hazardous Substances Data: 5052-95-9(Hazardous Substances Data)

Usage

General Description

1-Oxa-3,8-diazaspiro(4.5)decan 2-one is a chemical compound that belongs to the class of spiro compounds, which are characterized by a carbon atom linked to two different rings. It is a cyclic compound that contains a spiro nitrogen and oxygen atom. 1-Oxa-3,8-diazaspiro(4.5)decan 2-one has potential applications in pharmaceuticals, as it is structurally similar to some bioactive compounds and may have biological activity. Its spiro structure and oxygen-containing functional group make it an interesting target for synthesis and study in the field of medicinal chemistry. Additionally, its unique structure and potential biological activity make it a valuable compound for further research and potential drug development efforts.

Upstream product

• 177948-01-5 [[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]carbamic acid 1,1-dimethylethyl ester 
• 19867-34-6 N-benzyl-1-oxa-6-azaspiro[2,5]-octane 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 502482-52-2 2-[4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]acetic acid 
• 401811-97-0 4-ethoxycarbonylmethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 169206-55-7 2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester 
• 6094-60-6 1-benzyl-4-hydroxypiperidine-4-carbonitrile 
• 23804-68-4 4-(aminomethyl)-1-benzyl-4-hydroxypiperidine 
• 5053-14-5 8-Benzyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one 

Downstream Products

• 1538608-34-2 N-(2-amino-5-(4-methylthiophen-2-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide 
• 1538608-35-3 N-(4-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide 
• 1538608-36-4 N-(2-amino-5-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide 
• 1538608-37-5 N-(2-amino-5-(1-methyl-1H-imidazol-4-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide 
• 1538608-38-6 N-(2-aminophenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide 
• 1609198-60-8 C₂₆H₂₄ClF₃N₄O₃ 
• 1607837-47-7 8-(2-amino-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-3-(trifluoromethyl)pyridin-4-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one 

Relevant articles and documents

Spirocyclic derivatives

The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease, disorder or condition ameliorated by inhibition of a dopamine transporter); and methods of treating patients with such compounds; wherein R1, R2, R3, R4, R5, R6, R9, R10, Q, X, Y, Z, A, L, B, m, n and p are as defined herein.

AUTOTAXIN INHIBITOR COMPOUNDS

Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

Delayed and prolonged histone hyperacetylation with a selective HDAC1/HDAC2 inhibitor

The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow binding kinetics in isolated HDAC1 and HDAC2 preparations. Delayed histone hyperacetylation and