50525-00-3Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationships of 3-Arylisoquinolone Analogues as Highly Specific hCES2A Inhibitors
Zhao, Yitian,Xiong, Yuan,Dong, Sanfeng,Guan, Xiaoqing,Song, Yunqing,Yang, Yanqing,Zou, Kun,Li, Zhao,Zhang, Yong,Fang, Shengquan,Li, Bo,Zhu, Weiliang,Chen, Kaixian,Jia, Qi,Ge, Guangbo
, p. 388 - 398 (2020/10/26)
Mammalian carboxylesterases (CES) are key enzymes that participate in the hydrolytic metabolism of various endogenous and exogenous substrates. Human carboxylesterase 2A (hCES2A), mainly distributed in the small intestine and colon, plays a significant ro
Naphthopyranone synthesis via the tandem Michael-Dieckmann reaction of ortho-toluates with 5,6-dihydropyran-2-ones
Tan, Nichole P.H.,Donner, Christopher D.
, p. 4160 - 4162 (2008/09/20)
The tandem Michael-Dieckmann reaction between a series of ortho-toluates and the α,β-unsaturated lactone 25 is described. The tandem reaction delivers substituted naphthopyranones in moderate (20-49%) yields, whilst limitations in the tolerance of this reaction for different substituents on the ortho-toluate are identified. Crown Copyright
