5053-08-7 Usage
Pharmacological effects
As an α adrenergic and H1 histamine receptor antagonist, Fenspiride has been shown to be antiinflammatory, anti-allergic and antioxidant. Fenspiride inhibited SO2-induced goblet cell hyperplasia in rats, with concomitant inhibition of increased hexose and fucose, indicative of mucus hypersecretion, in lavage fluid. Fenspiride also exhibits neuronal inhibitory activity. For example, in guinea pigs, it reverses capsaicin-induced and citric acid-induced bronchoconstriction and cough, and inhibits cholinergic and non-adrenergic, non-cholinergic (NANC) neural contraction of isolated bronchi.
Indications
Fenspiride hydrochloride is a bronchodilator, which was used as a drug in the treatment of certain respiratory diseases. Finsecbili hydrochloride against serotonin, dilating bronchial smooth muscle, the intensity of action is between isoproterenol and theophylline, in addition to reducing the resistance of air movement in the lungs, experiments have shown that this product has dilated bronchial smooth muscle, antitussive, antipyretic and analgesic effects. Suitable for chronic bronchitis, bronchial asthma and chronic respiratory insufficiency.? In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis).
Chemical Properties
Pale Yellow Solid
Uses
Different sources of media describe the Uses of 5053-08-7 differently. You can refer to the following data:
1. Antiinflammatory;Bradykinin antagonist
2. Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
Therapeutic Function
Bronchodilator
Check Digit Verification of cas no
The CAS Registry Mumber 5053-08-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,5 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5053-08:
(6*5)+(5*0)+(4*5)+(3*3)+(2*0)+(1*8)=67
67 % 10 = 7
So 5053-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
5053-08-7Relevant articles and documents
Nitro-Aldol Approach for Commercial Manufacturing of Fenspiride Hydrochloride
Pramanik, Chinmoy,Bapat, Kiran,Patil, Pradip,Kotharkar, Sandeep,More, Yogesh,Gotrane, Dinkar,Chaskar, Sudhir P.,Mahajan, Ulhas,Tripathy, Narendra K.
, p. 1252 - 1256 (2019)
An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced following this new route meets the quality requirement NLT 99.70% purity by HPLC with any individual impurity NMT 0.10% with very good yield.
