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50541-93-0

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50541-93-0 Usage

Chemical Properties

clear colourless to light yellow liquid

Uses

4-Amino-1-benzylpiperidine was used in the preparation of:butyl 4-amino-1-piperidineacetate, key intermediate required for the synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one and 4-benzyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-isopropyl-1,2,4-thiadiazolidin-3-oneglycyrrhetinic acid derivatives

Purification Methods

Purify it by distillation in vacuo and store it under N2 because it absorbs CO2. The dihydrochloride salt [1205-72-7] has m 270-273o (255o) after recrystallisation from MeOH/EtOAc or EtOH. [Brookes J Chem Soc 3165, 3172 1957.] The 4-methylamino-1-benzylpiperidine derivative has b 168-172o/17mm, nD 1.5367 [Reitsema & Hunter J Am Chem Soc 70 4009 1948]. The 1-(1-benzyl-4-piperidinyl)-3-cyano-2-methylisothiourea derivative has m 160o from CHCl3/Et2O [Preparation, IR, NMR: Ried et al. Chem Ber 116 1547 1983, Beilstein 22 III/IV 3752].

Check Digit Verification of cas no

The CAS Registry Mumber 50541-93-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,5,4 and 1 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 50541-93:
(7*5)+(6*0)+(5*5)+(4*4)+(3*1)+(2*9)+(1*3)=100
100 % 10 = 0
So 50541-93-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2/c1-2-4-11(5-3-1)10-14-12-6-8-13-9-7-12/h1-5,12-14H,6-10H2

50541-93-0 Well-known Company Product Price

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  • Alfa Aesar

  • (A10149)  4-Amino-1-benzylpiperidine, 98%   

  • 50541-93-0

  • 5g

  • 464.0CNY

  • Detail
  • Alfa Aesar

  • (A10149)  4-Amino-1-benzylpiperidine, 98%   

  • 50541-93-0

  • 25g

  • 1364.0CNY

  • Detail
  • Alfa Aesar

  • (A10149)  4-Amino-1-benzylpiperidine, 98%   

  • 50541-93-0

  • 100g

  • 3673.0CNY

  • Detail
  • Aldrich

  • (195812)  4-Amino-1-benzylpiperidine  98%

  • 50541-93-0

  • 195812-5G

  • 466.83CNY

  • Detail
  • Aldrich

  • (195812)  4-Amino-1-benzylpiperidine  98%

  • 50541-93-0

  • 195812-25G

  • 1,359.54CNY

  • Detail
  • Aldrich

  • (195812)  4-Amino-1-benzylpiperidine  98%

  • 50541-93-0

  • 195812-100G

  • 3,657.42CNY

  • Detail

50541-93-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Amino-1-benzylpiperidine

1.2 Other means of identification

Product number -
Other names 1-Benzyl-4-aminopiperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50541-93-0 SDS

50541-93-0Relevant articles and documents

An improved scalable process for synthesis of piperidin-4-yl-carbamates

Devarasetty, Sitaramaiah,Nunna, Rambabu,Janni, Ravi,Pothuri, Vijai Varma,Suraparaju, Raghu Ram

, p. 775 - 777 (2018)

An efficient route for the synthesis of methyl piperidine-4-yl-carbamate para-toluene sulfonate salt has been developed. The synthesis involves the reductive amination of 1-benzylpiperidin-4-one with ammonia using Raney-Ni as a catalyst followed by de-protection of benzyl group and finally by making its salt. The advantage of this methodology includes use of easily available commercial raw materials and shorter reaction times with high yields makes this process most viable for large scale manufacturing methyl piperidine-4-yl-carbamate salts.

Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3- b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors

Park, Eunsun,Lee, Sun Joo,Moon, Heegyum,Park, Jongmi,Jeon, Hyeonho,Hwang, Ji Sun,Hwang, Hayoung,Hong, Ki Bum,Han, Seung-Hee,Choi, Sun,Kang, Soosung

, p. 958 - 979 (2021/02/01)

Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamide as a JAK1-selective scaffold, and the synthesis of various methyl amide derivatives provided 4-((cis-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (31g) as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of 31g (38a) exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of 31g on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-β-induced hepatic stellate cells (HSCs). Specifically, 31g significantly inhibited TGF-β-induced migration of HSCs at 0.25 μM in wound-healing assays.

Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

Yin, Liang,Zhang, Mingxue,He, Tiangeng

, p. 63 - 70 (2021/10/01)

In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts. Therefore, in the present article, we intended to develop novel thiazole-sulfonamide hybrids as a potent inhibitor of ALR2. These molecules significantly inhibited the ALR2 level in the rat lenses homogenate, where the most potent compound 7b showed activity comparable to sorbinil as standard. In Wistar rats, compound 7b improved the insulin level and body weight of the experimental animal together with a reduction in the glucose output. Compound 7b showed a significant reduction in the expression of ALR2 in rat lenses in western blot analysis.

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