50563-57-0Relevant academic research and scientific papers
ANOMALOUS RING OPENING OF N-ARYL-2-OXAZOLIDINONES BY ANHYDROUS ALKOXIDE:A CONVENIENT PREPARATION OF N-(ALKOXYETHYL)-2,6-DISUBSTITUTED ANILINES
Fancher, L.W.,Gless, R.D.,Wong, R.Y.
, p. 5095 - 5098 (2007/10/02)
N-(2-Alkoxyethyl)anilines may be prepared by acylation of an N-unsubstituted aniline with 2-chloroethyl chloroformate, ring closure to oxazolidinone, ring opening with alkoxide under anhydrous conditions to a carbamic acid salt, and decarboxylation.This unexpected mode of ring opening is especially useful in the preparation of N-(2-alkoxyethyl)-2,6-disubstituted anilines.
