50583-08-9Relevant academic research and scientific papers
Isolation and identification of some metabolites of bromazine from human urine
Goenechea,Eckhardt,Fahr
, p. 1580 - 1584 (2007/10/02)
In addition to the unchanged drug nine metabolites have been found in human urine after the administration of bromazine (2-(p-bromophenyl-phenylmethoxy)-1-N,N-dimethyl-ethylamine). Three compounds were extractable under alkaline conditions; they were identified as bromazine-N-oxide (II), N-monodesmethylbromazine (III) and N-didesmethylbromazine (IV). Two other substances were extractable under alkaline and acidic conditions, p-bromobenzhydrol (VI) and p-bromobenzophenone (VIII). Another metabolite - extractable at pH 7 - was p-hydroxybenzophenone (IX). Treatment of precipitated conjugated compounds with β-glucuronidase or hydrochloric acid resulted in the liberation of IV, VI and IX, all of which were also found as unconjugated compounds.
