5059-36-9

Usage

Uses

Used in Pharmaceutical Industry:
1-[2-(2,5-DIMETHYL-1H-PYRROL-1-YL)ETHYL]PIPERAZINE is used as a potential pharmaceutical agent for its structural features that may allow it to interact with biological systems, offering opportunities for the development of new drugs or therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 1-[2-(2,5-DIMETHYL-1H-PYRROL-1-YL)ETHYL]PIPERAZINE serves as a subject of study for understanding its chemical properties, reactivity, and potential applications in the synthesis of other compounds.
Used in Material Science:
1-[2-(2,5-DIMETHYL-1H-PYRROL-1-YL)ETHYL]PIPERAZINE may also find use in material science for the development of new materials with unique properties, given its structural composition and potential for interaction with other molecules.

InChI:InChI=1/C12H21N3/c1-11-3-4-12(2)15(11)10-9-14-7-5-13-6-8-14/h3-4,13H,5-10H2,1-2H3/p+2

Upstream product

• 110-85-0 piperazine 
• 110-13-4 2,5-hexanedione 
• 140-31-8 aminoethylpiperazine 

Downstream Products

• 52599-62-9 N-3,5-di-tert-butyl-4-hydroxybenzyl-N'-<β-(2,5-dimethyl-1-pyrryl)ethyl>piperazine 

Relevant academic research and scientific papers

Discovery and optimisation studies of antimalarial phenotypic hits

There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimise the physicochemical properties. The in vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09e29 mM, and generally good selectivity (typically >100-fold) compared to a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds.

SYNTHESIS OF AKALI AND HEAVY METAL DITHIO- AND THIOCARBAMATES BASED ON N-(β-AMINOETHYL)PIPERAZINE

A series of alkali and heavy metal dithio- and thiocarbamates based on N-(β-aminoethyl)piperazine and its derivatives N-(β-piperazinoethyl)imides, N-piperazine, and N-(β-salicylideneaminoethyl)piperazine is prepared.Methods for preparation of dithio- and thiocarbamates based on piperazine are improved.Alkali metal dithio- and thiocarbamates based on piperazines form polymeric complexes with heavy metals.