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Salicylic acid 5-sulfonohydrazide, also known as sulfisoxazole, is a chemical compound with the molecular formula C11H13N3O4S. It is a synthetic antibacterial agent belonging to the class of sulfonamide drugs, which are widely used in the treatment of various bacterial infections. salicylic acid 5-sulfonohydrazide works by inhibiting bacterial synthesis of dihydrofolic acid, an essential component for bacterial growth and reproduction. Salicylic acid 5-sulfonohydrazide is particularly effective against gram-negative bacteria and is commonly used in the treatment of urinary tract infections, respiratory infections, and otitis media. It is available in various pharmaceutical formulations, including tablets, suspensions, and injectable solutions, and is typically prescribed by healthcare professionals to manage bacterial infections in both adults and children.

5059-82-5

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5059-82-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5059-82-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,5 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5059-82:
(6*5)+(5*0)+(4*5)+(3*9)+(2*8)+(1*2)=95
95 % 10 = 5
So 5059-82-5 is a valid CAS Registry Number.

5059-82-5Relevant academic research and scientific papers

SALICYLIC ACID SULFONYL DERIVATIVES AND RELATED COMPOUNDS

Cremlyn, Richard,Swinbourne, Frederick,Plant, Stephen,Saunders, David,Sinderson, Colin

, p. 323 - 332 (2007/10/02)

Salicylic acid-5-sulfonohydrazide (3) has been condensed with β-dicarbonyl compounds to form pyrazoles (5).With ethyl acetoacetate, tri- and hexafluoropentane-2,4-dione the hydrazones (4) were obtained; although the former did cyclise in the presence of potassium carbonate-magnesium sulfate.With hexane-2,5-dione the pyrrole (7) was formed and not the pyridazine (8).Acylation of salicylic acid-5- and p-acetamidobenzene-sulfonohydrazides was examined; mono-acetates, benzoates and p-toluenesulfonates and diacetates are described, but other pure diacyl derivatives could not be i solated.Reaction with succinic and maleic anhydrides gave the corresponding amic acids (9, 10), and their cyclisation to pyridazines (11) was examined; only the maleamic acid (10) was converted to the pyridazine (11).Maleic hydrazide (14) by condensation with p-acetamido-benzenesulfonyl chloride gave the O-sulfonyl pyridazine (15). 5-Chlorosalicylic acid-3-sulfonohydrazide (18) was prepared and characterized as the acetone and cyclohexanone hydrazones (19); but attempts to make aromatic hydrazones gave the azines (20). 5-Chlorosalicylic acid-3-sulfonyl azide (21) reacted with norbornene and triphenylphosphine to give the aziridine (22) and the phosphinimine (23).

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