50596-31-1Relevant academic research and scientific papers
FLAVOR MODULATOR HAVING PYRIDINE DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT
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Paragraph 0127-0132, (2018/04/03)
2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active ingredient, a flavor of natural impression thereto; and in particular, when added to food and drink, the compound imparts an umami imparting or enhancing, a saltiness enhancing a sweetness enhancing, and in particular, when added to a milk or dairy product, a food or drink product containing a milk or dairy product, or a dairy replacement product, the compound provides a milk richness enhancing.
Aryloxypyridines
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, (2008/06/13)
Compounds of the formula STR1 wherein Py is a substituted or unsubstituted 2-, 3- or 4-pyridyl, N-oxidized or quaternized pyridyl group; A is a group of the formula (IIIA), (IIIB) or (IIIC) STR2 wherein ALK is straight or branched chain alkylene of 1 to 6 carbon atoms; R1 is a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group or acyl; R2, R3 and R4 are each hydrogen, a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group, acyl, hydroxy, alkoxy, aralkoxy, aryloxy, an esterified hydroxy group, nitro, halogen or amino; May be formulated into pharmaceutical compositions useful for the treatment of hyperglycaemia by combining said compounds with a pharmaceutically acceptable non-toxic inert diluent or carrier. Compounds of the formula STR3 wherein Py is a substituted or unsubstituted 2-, 3- or 4-pyridyl, N-oxidized or quaternized pyridyl group; A is a group of formula (IIIA), (IIIB) or (IIIC) STR4 wherein ALK is straight or branched chain alkylene of 1 to 6 carbon atoms; R1 is a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group or acyl; R2, r3 and R4 are each hydrogen, a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group, hydroxy, alkoxy, aralkoxy, aryloxy, an esterified hydroxy group, nitro, halogen, or amino, Provided that R1 is not methyl, cyano or methoxycarbonyl when Py is 2-pyridyl or 5-ethylpyrid-2-yl and A is [O--CH2 ]and R2, R3 and R4 are hydrogen or halogen, Are novel compounds per se. The compounds and compositions above described are useful for their hypoglycaemic activity and are useful in the treatment of hypoglycaemic conditions such as diabetes milletus.
