50597-60-9Relevant academic research and scientific papers
Computational analysis and synthesis of syringic acid derivatives as xanthine oxidase inhibitors
Dhiman, Priyanka,Khatkar, Anurag,Malik, Neelam
, p. 643 - 653 (2020/07/23)
Background: Xanthine oxidase (XO; EC 1.17.3.2) has been considered as a potent drug target for the cure and management of pathological conditions prevailing due to high levels of uric acid in the bloodstream. The role of xanthine oxidase has been well est
Synthesis and Estimation of Radical Scavenging Activity of Tetra(meso-aryl)porphyrins Containing 2,6-Dimethoxyphenol Unit
Rocheva,Mazaletskaya,Sheludchenko,Belykh
, p. 1635 - 1640 (2018/11/10)
Tetra(meso-aryl)porphyrins containing 2,6-dimethoxyphenol unit distant from the macrocycle and adjacent to it have been prepared. Radical scavenging activity of the obtained compounds has been estimated in the model reaction of ethylbenzene oxidation initiated by azobisisobutyronitrile. It has been shown that the phenol hydroxy group ability to inhibit ethylbenzene oxidation depends on the environment of phenol group.
Antibacterial Agents and Cystic Fibrosis: Synthesis and Antimicrobial Evaluation of a Series of N-Thiomethylazetidinones
Galletti, Paola,Cocuzza, Clementina E. A.,Pori, Matteo,Quintavalla, Arianna,Musumeci, Rosario,Giacomini, Daria
experimental part, p. 1919 - 1927 (2012/06/04)
The increasing emergence of multidrug-resistant microorganisms is one of the greatest challenges in the clinical management of infectious disease. New antimicrobial agents are therefore urgently required, particularly in the treatment of chronic and recurrent infections often associated with antibiotic-resistant pathogens, as in the case of cystic fibrosis (CF) patients. This study reports the antibacterial activity of a series of monocyclic β-lactams with an alkylidenecarboxyl chain or electron-withdrawing groups such as 4-OAc, 4-SAc, and 4-SO2Ph at the C4 position of the ring. N-Unsubstituted and N-thiomethyl derivatives were compared. A total of 33 azetidinones were tested for their activity against Gram-positive and Gram-negative bacterial clinical isolates. The combination of an N-thiomethyl group and a benzyl ester on the 4-alkylidene side chain were found to increase the potency against Gram-positive bacteria. The N-thiomethyl group clearly elevated the activity of 4-acetoxyazetidinones relative to the corresponding NH derivatives. The most active compounds showed minimum inhibitory concentration (MIC) values of 4 and 8mgL-1 against methicillin-resistant Staphylococcus aureus isolated from pediatric patients with CF.
Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach
Wu, Yu-Shan,Coumar, Mohane Selvaraj,Chang, Jang-Yang,Sun, Hsu-Yi,Kuo, Fu-Ming,Kuo, Ching-Chuan,Chen, Ying-Jun,Chang, Chi-Yen,Hsiao, Chia-Ling,Liou, Jing-Ping,Chen, Ching-Ping,Yao, Hsien-Tsung,Chiang, Yi-Kun,Tan, Uan-Kang,Chen, Chiung-Tong,Chu, Chang-Ying,Wu, Su-Ying,Yeh, Teng-Kuang,Lin, Chin-Yu,Hsieh, Hsing-Pang
supporting information; experimental part, p. 4941 - 4945 (2010/03/02)
BPR0L075 (2) is a potential anticancer drug candidate designed from Combretastatin A-4 (1) based on the bioisosterismprinciple.Metabolites of 2, proposed from in vitrohumanmicrosome studies,were synthesized, leading to the identification of metabolite-der
An efficient acid- and metal-free one-pot synthesis of benzothiazoles from carboxylic acids
Rudrawar, Santosh,Kondaskar, Atul,Chakraborti, Asit K.
, p. 2521 - 2526 (2007/10/03)
Carboxylic acids are converted to benzothiazoles in a one-pot reaction with thionyl chloride followed by treatment with 2-aminothiophenol under acid- and catalyst-free conditions. Georg Thieme Verlag Stuttgart.
