50598-37-3

Basic information

• Product Name: 2(3H)-Furanone, dihydro-4-methyl-4-phenyl-
• CAS NO: 50598-37-3
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 50598-37-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, dihydro-4-methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, dihydro-4-methyl-4-phenyl-(50598-37-3)
• EPA Substance Registry System: 2(3H)-Furanone, dihydro-4-methyl-4-phenyl-(50598-37-3)

Safety Data

• Hazardous Substances Data: 50598-37-3(Hazardous Substances Data)

Upstream product

• 52398-46-6 3-Methyl-4-oxo-3-phenyl-butyric acid methyl ester 
• 823213-94-1 4-methyl-4-phenyl-5-(p-tolylsulfanyl)dihydrofuran-2-one 
• 209391-68-4 (E)-1-[(1-chloro-2-phenylprop-1-en-1-yl)sulfinyl]-4-methylbenzene 
• 209391-69-5 (Z)-1-[(1-chloro-2-phenylprop-1-en-1-yl)sulfinyl]-4-methylbenzene 
• 823213-58-7 4-chloro-3,N,N-trimethyl-3-phenyl-4-(p-tolylsulfinyl)butanamide 
• 34713-70-7 2-Phenylpropanal 
• 136527-27-0 2,2-dichloro-3-methyl-3-phenylcyclobutan-1-one 
• 151990-53-3 3-methyl-3-phenylcyclobutan-1-one 
• 98-83-9 isopropenylbenzene 

Downstream Products

• 313219-82-8 3-[1-Dimethylamino-meth-(Z)-ylidene]-4-methyl-4-phenyl-dihydro-furan-2-one 

Relevant articles and documents

Baeyer–Villiger monooxygenase-catalyzed desymmetrizations of cyclobutanones. Application to the synthesis of valuable spirolactones

A series of γ-butyrolactone derivatives, including some spiranic ones, was obtained through desymmetrization of the corresponding prochiral 3-substituted cyclobutanones via Baeyer–Villiger monooxygenase (BVMO)-catalyzed oxidation. After reaction optimization using several commercial enzymes, both antipodes of various lactones were synthesized in most cases with >90% conversion and >80% enantiomeric excess under mild reaction conditions. In some cases alcohol formation was also observed (up to 40% conversion) as an undesired side reaction due to the presence of alcohol dehydrogenases in these preparations. Selected transformations were achieved on a 100 mg scale showing the possibilities of these oxidative biocatalysts as a new source of highly interesting compounds.

METHOD FOR MANUFACTURING ESTER

The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ε-caprolactone was obtained at an isolated yield of 82%.

Baeyer-villiger oxidation and oxidative cascade reactions with aqueous hydrogen peroxide catalyzed by lipophilic Li[B(C6F5) 4] and Ca[B(C6F5)4]2

Efficient and selective: Two lipophilic catalysts were used for Baeyer-Villiger (BV) oxidations to give lactones in high yields (see scheme). Cascade reactions involving this BV oxidation were used to selectively obtain either unsaturated carboxylic acids or hydroxylactones in high yields from β-silyl cyclohexanones. Copyright