50610-29-2

Upstream product

• 611-06-3 2,4-dichloronitrobenzene 
• 141-43-5 ethanolamine 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 342043-37-2 3,5-dichloro-2-nitroacetanilide 
• 71-36-3 butan-1-ol 

Downstream Products

• 100418-35-7 5-chloro-N-(2-mesyloxyethyl)-2-nitroaniline 
• 181870-03-1 2-[5-(1H-imidazol-1-yl)-2-nitroanilino]ethanol 
• 100417-17-2 3-(2-amino-5-chlorophenyl)-2-iminothiazolidine dihydrochloride 
• 100418-41-5 5-chloro-2-nitro-N-(2-thiocyanatoethyl)-aniline 
• 78056-11-8 2-<2-<(tert-butoxycarbonyl)amino>ethyl>-6-chloro-1-<2-(p-toluenesulfonyloxy)ethyl>benzimidazole 
• 78056-08-3 2-(2-aminoethyl)-6-chloro-1-(2-hydroxyethyl)benzimidazole dihydrochloride 
• 329922-72-7 2-(2-nitro-5-pyrrodidin-1-ylanilino)-1-ethanol 
• 91721-53-8 1-acetoxy-2-(N-acetyl-5-chloro-2-nitro-anilino)-ethane 
• 63387-85-9 2-[(2-amino-5-chlorophenyl)-amino]ethanol 

Relevant academic research and scientific papers

Regulating Cofactor Balance In Vivo with a Synthetic Flavin Analogue

A novel strategy to regulate cofactor balance in vivo for whole-cell biotransformation using a synthetic flavin analogue is reported. High efficiency, easy operation, and good applicability were observed for this system. Confocal laser scanning microscopy was employed to verify that the synthetic flavin analogue can directly permeate into Escherichia coli cells without modifying the cell membrane. This work provides a promising intracellular redox regulatory approach to construct more efficient cell factories.

CHEMICAL REGENERATION METHOD OF OXIDIZED COENZYME NAD (P)+

It discloses a chemical regeneration method of oxidized coenzyme NAD(P)+ which is under an oxygen or air atmosphere condition, adding a catalytic amount of bridged flavin, and oxidizing NAD(P)H to obtain NAD(P)+. The catalyst for regeneration of cofactor is cheap and easily available small organic molecule having no noble metal; this regeneration system can regenerate NADH and NADPH; this regeneration system has a wide pH range and temperature range, being applicable to various oxidation reactions catalyzed by nicotinamide-dependent oxidoreductase.

TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR

The invention relates to compounds of the formula (I) and their use as pharmaceutical ingredients, in particular for the treatment of CNS related diseases.

Chemoselective sulfide oxidation mediated by bridged flavinium organocatalysts

The chemoselective oxidation of sulfides to sulfoxides, catalysed by bridged, tetracyclic flavinium catalysts is presented. The flavinium catalysts are easily prepared via a telescoped three-step process. A range of sulfoxides is accessed in excellent yield and chemoselectivity.

Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene

Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.

N1,N10-Ethylene-bridged high-potential flavins: Synthesis, characterization, and reactivity

N1,N10-Ethyleneisoalloxazinium chloride and its 8-Cl-, 7-CF3-, and 3-CH3-7-CF3-substituted analogs were synthesized for the purpose of exhibiting thermal reactivity with organic substrates. The new flavins were characterized spectroscopically and electrochemically, and were found to react with amines, thiols, and phenylhydrazine, the latter case exhibiting catalytic aerobic recycling. Reactions of aliphatic benzylic and cyclopropyl amines with the 7-CF3 analog were also compared to their oxidations by tris(phenanthroline)iron(III). All reactions of the flavinium salts appear to occur through heterolytic rather than homolytic mechanisms.