50610-82-7

Usage

Type of compound

Heterocyclic organic compound

Structure

Quinoline ring system with a phenylmethyl group attached at the 2-position

Field of use

Medicinal chemistry and drug development

Potential properties

Pharmacological properties

Role in neurotransmission

Investigated for its potential involvement in neurobiological functions

Importance

Unique structure and potential biological activities for further exploration and study

Upstream product

• 6921-34-2 benzylmagnesium chloride 
• 1745-77-3 2-benzylquinoline 
• 1589-82-8 phenylmagnesium bromide 
• 137265-96-4 N-(2,3-dihydro-1H-inden-1-yl)-O-methylhydroxylamine 
• 91-22-5 quinoline 
• 118848-58-1 2-benzyl-1,2-dihydroquinoline 

Relevant academic research and scientific papers

Efficient entry into 2-substituted tetrahydroquinoline systems through alkylative ring expansion: Stereoselective formal synthesis of (±)-martinellic acid

(Chemical Equation Presented) A new efficient synthesis of 2-substituted tetrahydroquinolines has been achieved by the domino reaction of N-indanyl(methoxy)amines, which consists of three types of reactions: elimination of an alcohol, the rearrangement of an aryl group, and the addition of an organolithium or magnesium reagent. The synthetic utility of this approach is demonstrated by the stereoselective formal synthesis of (±)- martinellic acid.

Asymmetric hydrogenation of quinolines catalyzed by iridium complexes of monodentate BINOL-derived phosphoramidites

The monodentate BINOL-derived phosphoramidite PipPhos is used as ligand for the iridium-catalyzed asymmetric hydrogenation of 2- and 2,6-substituted quinolines. If tri-ortho-tolylphosphine and/or chloride salts are used as additives enantioselectivities are strongly enhanced up to 89%. NMR indicates that no mixed complexes are formed upon addition of tri-ortho-tolylphosphine.

Hypoglycemic thiazolidinediones

Hypoglycemic 5-[1-(5,6,7,8-tetrahydro-2-napthyl-; 1,2,3,4-tetrahydro-6-quinolyl-; 2-indanyl-; and 2-indolyl)alkyl]thiazolidine-2,4-dione derivatives, pharmaceutically acceptable salts thereof, and a method for their use in the treatment of hyperglycemic mammals.