50613-36-0Relevant academic research and scientific papers
Synthesis and biological activity of 5′,9-anhydro-3-purine- isonucleosides as potential anti-hepatitis C virus agents
Chun, Byoung-Kwon,Wang, Peiyuan,Hassan, Abdalla,Du, Jinfa,Tharnish, Phillip M.,Murakami, Eisuke,Stuyver, Lieven,Otto, Michael J.,Schinazi, Raymond F.,Watanabe, Kyoichi A.
, p. 83 - 97 (2007)
In order to study structure-activity relationships among the derivatives and congeners of 5′,9-anhydro-3-(β-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5′,9-anhydro-purine- isonucleosides with a substituent (s) at 6- or/and 8
5,6-Diaminocytidine, a versatile synthon for pyrimidine-based bicyclic nucleosides
Rajeev, Kallanthottathil G.,Broom, Arthur D.
, p. 3595 - 3598 (2007/10/03)
(matrix presented) This communication describes a convenient, facile, and high-yield synthesis of 3-(β-D-ribofuranosyl)isoguanine and its 8-methyl derivative, as well as nucleoside analogues of pteridines, from a common precursor, 5,6-diaminocytidine. 5,6
A NOVEL AND EFFICIENT SYNTHESIS OF ISOGUANOSINE
Chern, Ji-Wang,Lee, Horng-Yuh,Huang, Min,Shish, Fang-Jy
, p. 2151 - 2154 (2007/10/02)
Isoguanosine (4b) was synthesized by a one-pot reaction involving a condensation of 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (1b) with benzoyl isothiocyanate, treatment of the resulting thiourea derivative with DCC furnished 5-(N1-benzoylcarbamoyl)aminoimidazole-4-carbonitrile (3b) which was then annulated with ethanolic ammonia to afford isoguanosine in a 68percent yield from 1b.
