50615-92-4Relevant academic research and scientific papers
Supramolecular catalysis of Strecker reaction in water under neutral conditions in the presence of β-cyclodextrin
Surendra,Srilakshmi Krishnaveni,Mahesh,Rama Rao
, p. 2532 - 2534 (2006)
An environmentally benign and highly efficient procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) has been developed under biomimetic conditions in water in the presence of β-cyclodextrin to afford α-aminonitriles in quantitative yields. The use of cyclodextrin precludes the use of either acid or base, and the catalyst can be recycled a number of times without loss in activity.
