506427-46-9Relevant academic research and scientific papers
Synthesis of Fused Tetrazole Derivatives via a Tandem Cycloaddition and N-Allylation Reaction and Parallel Synthesis of Fused Tetrazole Amines
Ek, Fredrik,Manner, Sophie,Wistrand, Lars-Goeran,Frejd, Torbjoern
, p. 1346 - 1352 (2007/10/03)
A method for the synthesis of novel fused tricyclic tetrazoles from allylic bromides generated by the recently discovered DiazAll reaction has been developed. This new tandem reaction comprises a cycloaddition between a nitrile and (TMS)N3 followed by an intramolecular N-allylation. The variation of functionalities in the benzene moiety was well-tolerated, and only a moderate difference in yield and degree of purity was noticed. An exo-methylene group in these new compounds permitted further derivatization. Structural resemblance with substances which possess important pharmacological properties motivated the synthesis of a series of ketones and a small library of amines.
Aromatic allylation via diazotization: Variation of the allylic moiety and a short route to a benzazepine derivative
Ek, Fredrik,Wistrand, Lars-Goeran,Frejd, Torbjoern
, p. 1911 - 1918 (2007/10/03)
A continued study of the recently discovered diazotizative allylation (DiazAll) reaction of aniline derivatives is reported. Several allyl reagents, commonly used in radical allylation reactions, were evaluated, and some of these reagents resulted in ally
