506437-35-0Relevant academic research and scientific papers
One-pot synthesis of pyrroles using a titanium-catalyzed multicomponent coupling procedure
Pasko, Cody M.,Dissanayake, Amila A.,Billow, Brennan S.,Odom, Aaron L.
, p. 1168 - 1176 (2016/02/16)
A simple one-pot procedure for the production of 2-carboxylpyrroles with 4-alkyl, 5-alkyl, 4-aryl, 4-aryl-5-alkyl, or 3,4-diaryl substitution patterns is presented. The procedure involves the titanium-catalyzed multicomponent coupling of alkynes, primary amines and isonitriles to give 1,3-diimines in situ; the multicomponent product is then treated with the ethyl ester of glycine hydrochloride to give the NH-pyrrole. The reaction can be carried out with the neutralized glycine ester or with the hydrochloride salt using DBU as a base. Yields of pyrrole based on starting alkyne varied from 25 to 65% over the one pot procedure, and in most cases only one regioisomer of the product is observed. Further, it is proposed that the regioselectivities of the reactions are a result of rate-determining ring closure after relatively fast transimination with glycine ethyl ester.
Pyrazole synthesis using a titanium-catalyzed multicomponent coupling reaction and synthesis of withasomnine
Majumder, Supriyo,Gipson, Kevin R.,Staples, Richard J.,Odom, Aaron L.
experimental part, p. 2013 - 2023 (2011/02/28)
The titanium-catalyzed 3-component coupling of an alkyne, isonitrile, and amine can be used to generate tautomers of 1,3-diimines. These diimines produced in situ undergo cyclization with hydrazine and hydrazine derivatives in a one-pot procedure to provi
