506439-68-5Relevant academic research and scientific papers
Enantioselective Oxetane Ring Opening with Chloride: Unusual Use of Wet Molecular Sieves for the Controlled Release of HCl
Yang, Wen,Wang, Zhaobin,Sun, Jianwei
supporting information, p. 6954 - 6958 (2016/06/13)
An unprecedented enantioselective oxetane opening with chloride provides access to a range of highly functionalized three-carbon building blocks. The excellent enantiocontrol is enabled not only by a new catalyst, but also by the unusual use of wet molecular sieves for the controlled release of HCl. The enantioselective ring opening of oxetanes with chloride provides access to a range of highly functionalized three-carbon building blocks. The use of a new catalyst in combination with wet molecular sieves for the controlled release of HCl leads to high enantioselectivities.
Enzymatic transformations. Part 55: Highly productive epoxide hydrolase catalysed resolution of an azole antifungal key synthon
Monfort, Nicolas,Archelas, Alain,Furstoss, Roland
, p. 601 - 605 (2007/10/03)
A highly productive bioprocess for the preparation of enantiopure azole antifungal chirons is described. These are key building blocks for the synthesis of new triazole drug derivatives known to display valuable activity against such infections as for ins
Enzymatic transformations. Part 53: Epoxide hydrolase-catalysed resolution of key synthons for azole antifungal agents
Monfort, Nicolas,Archelas, Alain,Furstoss, Roland
, p. 2399 - 2401 (2007/10/03)
The biocatalysed hydrolytic kinetic resolution (BHKR) of a key building block allowing the synthesis of an enantiopure azole antifungal compound is described. This is based on the epoxide hydrolase-catalysed resolution of a racemic epoxide. Using epoxide
